Results 71 to 80 of about 404,021 (295)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Decentralized Optimal Reactive Power Dispatch of Optimally Partitioned Distribution Networks

IEEE Access, 2018
This paper proposes a two-stage decentralized optimal reactive power dispatch (D-ORPD) framework, which considers the network partitioning influence in distributed optimization.
Peishuai Li, Zaijun Wu, Ke Meng, Guo Chen, Zhao Yang Dong   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimal Reactive Power Dispatch Planning Considering Voltage Deviation Minimization in Power Systems

Energies
Transmission lines in electrical power systems are studied and analyzed to improve the electrical system’s safety, stability, and optimal operation. Past research has proposed various optimization methods to address the problem of active and reactive ...
Orlando Álvarez, Diego Carrión, Manuel Jaramillo   +2 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Assessment and enhancement of transfer capability for large-scale renewable generation base transmitted by voltage source converter based high voltage direct current system

International Journal of Electrical Power & Energy Systems
Voltage source converter based high voltage direct current transmission is a key method for transmitting large-scale renewable energy generation. The transfer capability of large-scale renewable generation base transmitted by voltage source converter ...
Shiyuan Chen, Shunjiang Lin, Yuerong Yang, Kaiyun Jiang, Mingbo Liu   +4 more
doaj   +1 more source

Optimal Voltage Regulation of Unbalanced Distribution Networks with Coordination of OLTC and PV Generation

, 2019
Photovoltaic (PV) smart inverters can regulate voltage in distribution systems by modulating reactive power of PV systems. In this paper, an optimization framework for optimal coordination of reactive power injection of smart inverters and tap operations
Disfani, Vahid, Haghi, Hamed Valizadeh, Kleissl, Jan, Li, Changfu   +3 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Model-Free Optimal Volt-VAR Control of Wind Farm Based on Data-Driven Lift-Dimension Linear Power Flow

CSEE Journal of Power and Energy Systems
This paper proposes a reactive power and voltage optimal control method for wind farms based on data-driven power flow. Because no prior knowledge of wind farm parameters is necessary, the proposed method is model-free.
Li Guo, Zhaoning Liu, Zhongguan Wang, Xialin Li, Yixin Liu, Yuxuan Zhang, Xiaodi Zang, Chengshan Wang   +7 more
doaj   +1 more source