Results 71 to 80 of about 478,709 (297)

ILOOP – a web application for two-channel microarray interwoven loop design

BMC Genomics, 2008
Microarray technology is widely applied to address complex scientific questions. However, there remain fundamental issues on how to design experiments to ensure that the resulting data enables robust statistical analysis.
Perkins Edward J, Yang Mary, Yang Jack Y, Gong Ping, Pirooznia Mehdi, Deng Youping   +5 more
doaj   +1 more source

Optimal designs for asymmetric sigmoidal response curves in bioassays and immunoassays [PDF]

, 2017
Recent studies show that asymmetric sigmoidal response curves are not uncommonin biomedical studies. For example, the 5-parameter logistic (5PL) model isfrequently used to model and analyze responses from bioassays and immunoassayswhich can be skewed ...
Hyun, Seung Won, Wong, Weng Kee, Yang, Yarong   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A Non-Parametric Sequential Procedure for the Generalized Partition Problem

Mathematics
In selection and ranking, the partitioning of treatments by comparing them to a control treatment is an important statistical problem. For over eighty years, this problem has been investigated by a number of researchers via various statistical designs to
Tumulesh K. S. Solanky, Jie Zhou
doaj   +1 more source

Some recent developments in the design of adaptive clinical trials

Statistica, 2013
For clinical trials that compare two or more competing treatments, the literature proposes several randomization rules that aim at favouring, at each stage of the trial, the treatment that appears to be best.
Alessandro Baldi Antognini, Alessandra Giovagnoli, Maroussa Zagoraiou   +2 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

POBE: A Computer Program for Optimal Design of Multi-Subject Blocked fMRI Experiments

Journal of Statistical Software, 2014
For functional magnetic resonance imaging (fMRI) studies, researchers can use multi-subject blocked designs to identify active brain regions for a certain stimulus type of interest.
Bärbel Maus, Gerard van Breukelen
doaj   +1 more source

Research of the influence of technological defects on the reinforcement of statistical stress fields in composite materials of quadrocopter blades

Известия высших учебных заведений. Поволжский регион:Технические науки, 2023
Background. Improving designs, expanding the range and increasing the production of quadrocopters are stable global trends. Progressive technical solutions, new materials, modern microelectronics are used in the designs of quadrocopters.
E.D. Kartashova
doaj   +1 more source