Results 111 to 120 of about 78,187 (304)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach   +23 more
wiley   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez   +10 more
wiley   +1 more source

Optimal stopping made easy [PDF]

open access: yes
This paper presents a simple discrete time model for valuing real options. A short proof of optimal exercise rules for the standard problems in the real options theory is given in the binomial and trinomial models, and more generally, when the underlying
Sergey Levendorskiy   +1 more
core  

Belief-Based Model of Career Dropout Under Monopsonistic Employment and Noisy Evaluation

open access: yesMathematics
This paper develops a belief-based dynamic optimisation framework to explain career continuation decisions in settings characterised by monopsonistic employment and asymmetric performance evaluation.
Iñaki Aliende   +2 more
doaj   +1 more source

Optimal Timing to Trade along a Randomized Brownian Bridge

open access: yesInternational Journal of Financial Studies, 2018
This paper studies an optimal trading problem that incorporates the trader’s market view on the terminal asset price distribution and uninformative noise embedded in the asset price dynamics.
Tim Leung, Jiao Li, Xin Li
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi   +5 more
wiley   +1 more source

Optimal stopping under uncertainty in drift and jump intensity

open access: yes, 2018
This paper studies the optimal stopping problem in the presence of model uncertainty (ambiguity). We develop a numerically implementable method to solve this problem in a general setting, allowing for general time-consistent ambiguity-averse preferences ...
Krätschmer, V.   +10 more
core   +1 more source

Semi-tractability of optimal stopping problems via a weighted stochastic mesh algorithm [PDF]

open access: yes, 2019
In this article we propose a Weighted Stochastic Mesh (WSM) algorithm for approximating the value of discrete and continuous time optimal stopping problems.
Schoenmakers, John   +7 more
core   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

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