Results 71 to 80 of about 292,252 (254)
Portfolio optimisation models and properties of return distributions [PDF]
, 2004 Mean-risk models have been widely used in portfolio optimisation. However, such models may produce portfolios that are dominated with respect to second order stochastic dominance and therefore not optimal for rational and risk-averse investors.
Darby-Dowman, K, Mitra, G, Roman, D
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Using a bootstrap method to choose the sample fraction in tail index estimation [PDF]
Tail index estimation depends for its accuracy on a precise choice of the sample fraction, i.e. the number of extreme order statistics on which the estimation is based.
Danielsson, J. +3 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Journal of Geophysical Research: Machine Learning and ComputationVelocity distribution functions (VDFs) measured by the Magnetospheric Multiscale (MMS) mission are complex 3D data sets that can be represented as a superposition of multiple beams.
Beniamino Sanò +6 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Thyroid cancer imaging in vivo by targeting the anti-apoptotic molecule galectin-3.
PLoS ONE, 2008 BackgroundThe prevalence of thyroid nodules increases with age, average 4-7% for the U.S.A. adult population, but it is much higher (19-67%) when sub-clinical nodules are considered.
Armando Bartolazzi +11 more
doaj +1 more source
Acta Informatica PragensiaBackground: Feature selection methods play a crucial role in handling challenges such as imbalanced classes, noisy data and high dimensionality. However, existing techniques, including swarm intelligence and set theory approaches, often struggle with high-dimensional datasets due to repeated reassessment of feature selection, leading to increased ...
Said Al Afghani Edsa, Khamron Sunat
openaire +2 more sources
A Comparison of Parametric and Sampling Approaches to Portfolio Investment Selection using FTSE100 Stocks [PDF]
In this paper we assess the effectiveness of two approaches to portfolio selection: the more customary parametric approach and a sampling approach using a sample of two years of daily data for the top 100 UK stocks for a period from the beginning of 2006
David E. Allen +1 more
core
Distributed Learning and Multiaccess of On-Off Channels
, 2013 The problem of distributed access of a set of N on-off channels by ...
Chen, Shiyao, Tong, Lang
core +1 more source