Results 101 to 110 of about 1,379,735 (279)
Optimal Transport for Diffeomorphic Registration [PDF]
, 2017 This paper introduces the use of unbalanced optimal transport methods as a similarity measure for diffeomorphic matching of imaging data. The similarity measure is a key object in diffeomorphic registration methods that, together with the regularization on the deformation, defines the optimal deformation. Most often, these similarity measures are local
Feydy, Jean +3 more
openaire +4 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Quadratic-form optimal transport
Mathematical ProgrammingWe introduce the framework of quadratic-form optimal transport (QOT), whose transport cost has the form $\iint c\,\mathrm{d}π\otimes\mathrm{d}π$ for some coupling $π$ between two marginals. Interesting examples of quadratic-form transport cost and their optimization include inequality measurement, the variance of a bivariate function, covariance ...
Ruodu Wang, Zhenyuan Zhang
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Optimal-Transport-Based Positive and Unlabeled Learning Method for Windshear Detection
Remote SensingWindshear is a microscale meteorological phenomenon that can be dangerous to aircraft during the take-off and landing phases. Accurate windshear detection plays a significant role in air traffic control.
Jie Zhang +2 more
doaj +1 more source
On the Ramified Optimal Allocation Problem
, 2011 This paper proposes an optimal allocation problem with ramified transport technology in a spatial economy. Ramified transportation is used to model the transport economy of scale in group transportation observed widely in both nature and efficiently ...
Xia, Qinglan, Xu, Shaofeng
core
Climate Optimized Air Transport
, 2012 Aviation climate impact is caused by CO2 and non-CO2 emissions where the climate effect of non-CO2 emissions depends on weather and aircraft route. An aviation system with minimum climate impact differs from a system with minimum emissions. Considerable potential exists to reduce the climate impact of aviation by weather- and cost-dependent climate ...
Matthes, Sigrun +6 more
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source