Results 91 to 100 of about 238,335 (283)
, 1999 This is an introduction to Optimality Theory, whose central idea is that surface forms of language reflect resolutions of conflicts between competing constraints. A surface form is 'optimal' if it incurs the least serious violations of a set of constraints, taking into account their hierarchical ranking.
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
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Optimal growth path in an OLG economy without time-preference assumptions : main results [PDF]
The aim is to characterize optimal growth paths in an OLG economy where capital accumulation is achieved through bequests, without using the assumption of time preference theory on a social level, because such an assumption, that leads to use a ...
Mohamed Mabrouk
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
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A bidirectional Optimality Theoretic analysis of multiple negative indefinites in Afrikaans
Stellenbosch Papers in Linguistics, 2014 In the literature on negation, Afrikaans is generally categorised as a negative concord language. Unlike most other negative concord languages though, utterances containing multiple indefinites in the scope of negation are typically produced with a ...
Huddlestone, Kate, de Swart, Henriëtte
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
SSRN Electronic Journal, 2019 In this paper optimal income taxation theories are subject of investigation following the classic paper in public finance by Mirrlees (1971), than the models of Sadka (1976), Seade,(1977), Akerlof (1978), Stiglitz (1982), Diamond (1998), and Saez (2001), Piketty-Saez-Stantcheva (2014), all related to the classic paper by Mirrlees (1971). The problem is
Josheski, Dushko, Boskov, Tatjana
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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