Results 81 to 90 of about 5,463,307 (266)
Evaluating the complexity of optimality theory
, 2009 Idsardi (2006) claims that Optimality Theory (OT; Prince and Smolensky (1993/2004) is "in general computationally intractable" on the basis of a proof adapted from Eisner (1997). We take issue with this conclusion on two grounds.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Autosegmental spreading in optimality theory
, 2011 This paper is a shorter version of ROA-1009 'Harmony in harmonic serialism'. Some material is omitted, but the overall presentation is probably clearer.The publisher of the book in which this excerpt appears does not permit the archiving of this or any ...
core
, 2021 Optimality of syntactic dependency distances Preprocessed data and code for the article Optimality of Syntactic Dependency Distances. This is the first release of the Optimality of Syntactic Dependency Distances repository at Github.com. The sole purpose
Carlos Gómez-Rodríguez +2 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
A bidirectional Optimality Theoretic analysis of multiple negative indefinites in Afrikaans
Stellenbosch Papers in Linguistics, 2014 In the literature on negation, Afrikaans is generally categorised as a negative concord language. Unlike most other negative concord languages though, utterances containing multiple indefinites in the scope of negation are typically produced with a ...
Huddlestone, Kate, de Swart, Henriëtte
doaj +1 more source
Asymptotic Optimality Theory for Active Quickest Detection with Unknown PostChange Parameters. [PDF]
Seq Anal, 2023 Xu Q, Mei Y.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Coordination of plant hydraulic and photosynthetic traits: confronting optimality theory with field measurements. [PDF]
New Phytol, 2021 Xu H +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source