Results 81 to 90 of about 23,247 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Approximation and Exactness in Finite State Optimality Theory [PDF]

open access: yes, 2000
Previous work (Frank and Satta 1998; Karttunen, 1998) has shown that Optimality Theory with gradient constraints generally is not finite state. A new finite-state treatment of gradient constraints is presented which improves upon the approximation of ...

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Hypocoristic names as the pattern of the representing the verbal protest and satisfying in Kermanshah Kurdish [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2015
The current study investigates the patterns for forming hypocoristic names used to represent verbal protest and satisfaction in relation to three social factors: gender, age and context.
Bahman Haidari
doaj  

PARETO-OPTIMALITY AND L-OPTIMAL FOR SOLVING SOME CLASSES OF OPTIMAL CONTROL PROBLEM

open access: yesФинансы: теория и практика, 2017
Many practical problems of economic activities and a number of important issues of economic theory are connected to the choice of optimal solution. An adequate economic theory should reflect the process of continuous development of the economic system ...
V. V. Kiselev
doaj   +1 more source

THEORETICAL IMPLICATIONS OF OCP EFFECTS ON FEATURES IN OPTIMALITY THEORY [PDF]

open access: yes, 1999
This dissertation applies Optimality Theory (OT: Prince and Smolensky 1993) to furnish a typological study of the effects of the Obligatory Contour Principle (OCP) on features. In OT, language-particular differences are described by different rankings of
Fukazawa, Haruka, Haruka Fukazawa
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Schwa in Contemporary Standard Russian

open access: yesPoljarnyj Vestnik: Norwegian Journal of Slavic Studies, 2000
This article explores a number of generalizations regarding the distribution of schwa in Russian and outlines an analysis in terms of Optimality Theory.
Tore Nesset
doaj   +1 more source

Optimization in Theory and Practice

open access: yesCoRR
Algorithms for continuous optimization problems have a rich history of design and innovation over the past several decades, in which mathematical analysis of their convergence and complexity properties plays a central role. Besides their theoretical properties, optimization algorithms are interesting also for their practical usefulness as computational
openaire   +2 more sources

Alignment and adjacency in optimality theory : evidence from Warlpiri and Arrernte [PDF]

open access: yes, 1998
The goal of this thesis is to explore alignment and adjacency of constituents in the framework of Optimality Theory. Under the notion of alignment, certain categories, prosodic and morphological, are required to correspond to certain other categories ...
Berry, Lynn, Berry, L.
core   +1 more source

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