Results 31 to 40 of about 87,577 (219)

“Pharmacotrophy”: a playful tournament for game- and team-based learning in pharmacology education - assessing its impact on students’ performance

BMC Medical Education
Background At the Faculty of Pharmacy of Paris, we conducted a pharmacology tournament in 2021 and 2022, named “Pharmacotrophy”, to offer a game-, team- and competitive-based learning innovation based on fun and challenge.
Clément Delage, Maeva Palayer, Dominique Lerouet, Valérie C. Besson   +3 more
doaj   +1 more source

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

Brain Sciences, 2022
Introduction: Cocaine use disorder is a chronic disease with severe consequences and a high relapse rate. There is a critical need to explore the factors influencing relapse in order to achieve more efficient treatment outcomes.
Margaux Poireau, Thomas Milpied, Angéline Maillard, Christine Delmaire, Emmanuelle Volle, Frank Bellivier, Romain Icick, Julien Azuar, Cynthia Marie-Claire, Vanessa Bloch, Florence Vorspan   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Influence of Sampling Frequency Ratio on Mode Mixing Alleviation Performance: A Comparative Study of Four Noise-Assisted Empirical Mode Decomposition Algorithms

Machines, 2021
Four noise-assisted empirical mode decomposition (EMD) algorithms, i.e., ensemble EMD (EEMD), complementary ensemble EMD (CEEMD), complete ensemble EMD with adaptive noise (CEEMDAN), and improved complete ensemble EMD with adaptive noise (ICEEMDAN), are ...
Yanqing Zhao, Kondo H. Adjallah, Alexandre Sava, Zhouhang Wang   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improving communication with individuals experiencing Behavioural and Psychological Symptoms of Dementia (BPSD): an evaluative study of a co-designed video-based training programme for health professionals

BMC Geriatrics
Background Behavioural and psychological symptoms of dementia (BPSD) are common, distressing manifestations of major neurocognitive disorders. Ineffective health professional communication exacerbates these symptoms, while conventional training rarely ...
Hermine Lenoir, Sébastien Dacunha, Lauriane Blavette, Maribel Pino, Anne-Sophie Rigaud   +4 more
doaj   +1 more source

Continuous Patient Monitoring With a Patient Centric Agent: A Block Architecture

IEEE Access, 2018
The Internet of Things (IoT) has facilitated services without human intervention for a wide range of applications, including continuous remote patient monitoring (RPM).
Md. Ashraf Uddin, Andrew Stranieri, Iqbal Gondal, Venki Balasubramanian   +3 more
doaj   +1 more source

Methylomic Biomarkers of Lithium Response in Bipolar Disorder: A Proof of Transferability Study

Pharmaceuticals, 2022
Response to lithium (Li) is highly variable in bipolar disorders (BD) and no clinical or biological predictors of long-term response have been validated to date.
Cynthia Marie-Claire, Cindie Courtin, Frank Bellivier, Jan Scott, Bruno Etain   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source