Results 31 to 40 of about 88,363 (267)

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

Pharmaceuticals, 2022
Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned.
Camille Lagard, Dominique Vodovar, Lucie Chevillard, Jacques Callebert, Fabien Caillé, Géraldine Pottier, Hao Liang, Patricia Risède, Nicolas Tournier, Bruno Mégarbane   +9 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

“Pharmacotrophy”: a playful tournament for game- and team-based learning in pharmacology education - assessing its impact on students’ performance

BMC Medical Education
Background At the Faculty of Pharmacy of Paris, we conducted a pharmacology tournament in 2021 and 2022, named “Pharmacotrophy”, to offer a game-, team- and competitive-based learning innovation based on fun and challenge.
Clément Delage, Maeva Palayer, Dominique Lerouet, Valérie C. Besson   +3 more
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Three optimisations for sharing [PDF]

Theory and Practice of Logic Programming, 2003
To improve precision and efficiency, sharing analysis should track both freeness and linearity. The abstract unification algorithms for these combined domains are suboptimal, hence there is scope for improving precision. This paper proposes three optimisations for tracing sharing in combination with freeness and linearity. A novel connection between
Jacob M. Howe, Andy King
openaire   +3 more sources

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

Brain Sciences, 2022
Introduction: Cocaine use disorder is a chronic disease with severe consequences and a high relapse rate. There is a critical need to explore the factors influencing relapse in order to achieve more efficient treatment outcomes.
Margaux Poireau, Thomas Milpied, Angéline Maillard, Christine Delmaire, Emmanuelle Volle, Frank Bellivier, Romain Icick, Julien Azuar, Cynthia Marie-Claire, Vanessa Bloch, Florence Vorspan   +10 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Improving communication with individuals experiencing Behavioural and Psychological Symptoms of Dementia (BPSD): an evaluative study of a co-designed video-based training programme for health professionals

BMC Geriatrics
Background Behavioural and psychological symptoms of dementia (BPSD) are common, distressing manifestations of major neurocognitive disorders. Ineffective health professional communication exacerbates these symptoms, while conventional training rarely ...
Hermine Lenoir, Sébastien Dacunha, Lauriane Blavette, Maribel Pino, Anne-Sophie Rigaud   +4 more
doaj   +1 more source

Influence of Sampling Frequency Ratio on Mode Mixing Alleviation Performance: A Comparative Study of Four Noise-Assisted Empirical Mode Decomposition Algorithms

Machines, 2021
Four noise-assisted empirical mode decomposition (EMD) algorithms, i.e., ensemble EMD (EEMD), complementary ensemble EMD (CEEMD), complete ensemble EMD with adaptive noise (CEEMDAN), and improved complete ensemble EMD with adaptive noise (ICEEMDAN), are ...
Yanqing Zhao, Kondo H. Adjallah, Alexandre Sava, Zhouhang Wang   +3 more
doaj   +1 more source