Results 41 to 50 of about 690,038 (285)

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

Pharmaceuticals, 2022
Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned.
Camille Lagard, Dominique Vodovar, Lucie Chevillard, Jacques Callebert, Fabien Caillé, Géraldine Pottier, Hao Liang, Patricia Risède, Nicolas Tournier, Bruno Mégarbane   +9 more
doaj   +1 more source

Deterministic and robust optimisation strategies for metal forming proceesses [PDF]

, 2007
Product improvement and cost reduction have always been important goals in the metal forming industry. The rise of\ud Finite Element simulations for metal forming processes has contributed to these goals in a major way.
Bonte, M.H.A., Boogaard, A.H. van den, Huetink, J.   +2 more
core   +1 more source

Tiltrotor CFD part II: aerodynamic optimisation of tiltrotor blades [PDF]

, 2017
This paper presents aerodynamic optimisation of tiltrotor blades with high-fidelity computational fluid dynamics. The employed optimisation framework is based on a quasi-Newton method, and the required high-fidelity flow gradients were computed using a
Barakos, G.N., Baverstock, K.D., Biava, M., Gates, S., Jimenez Garcia, A., Mullen, P.   +5 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Towards individualised treatment of urinary tract infections

Communications Medicine
Monitoring host- and pathogen-specific biomarkers alongside drug levels at the site of infection offers promise for personalised antimicrobial therapy.
Ellen V. Stadler, Alison Holmes, Danny O’Hare, Timothy M. Rawson   +3 more
doaj   +1 more source

FREE SEARCH – A NOVEL HEURISTIC METHOD [PDF]

, 2003
Key words to describe the work: Evolutionary computing, Artificial Intelligence, Free Search. Key Results: Inspired from the nature new population-based algorithm applied to numerical optimisation. How does the work advance the state-of-the-art?: Novel
Littlefair, Guy, Penev, Kalin
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

“Pharmacotrophy”: a playful tournament for game- and team-based learning in pharmacology education - assessing its impact on students’ performance

BMC Medical Education
Background At the Faculty of Pharmacy of Paris, we conducted a pharmacology tournament in 2021 and 2022, named “Pharmacotrophy”, to offer a game-, team- and competitive-based learning innovation based on fun and challenge.
Clément Delage, Maeva Palayer, Dominique Lerouet, Valérie C. Besson   +3 more
doaj   +1 more source

Biomarkers of Relapse in Cocaine Use Disorder: A Narrative Review

Brain Sciences, 2022
Introduction: Cocaine use disorder is a chronic disease with severe consequences and a high relapse rate. There is a critical need to explore the factors influencing relapse in order to achieve more efficient treatment outcomes.
Margaux Poireau, Thomas Milpied, Angéline Maillard, Christine Delmaire, Emmanuelle Volle, Frank Bellivier, Romain Icick, Julien Azuar, Cynthia Marie-Claire, Vanessa Bloch, Florence Vorspan   +10 more
doaj   +1 more source