Results 61 to 70 of about 33,603 (293)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Optimisation Technique For Perfect Pairing
, 2023 Abstract Research focuses on the aspects of finding ideal pairs among ’n’ entities under specified constraints. The entities are assumed to be perfectly logical and possess quantifiable properties only. Each entity given a set of criteria is expected to rate itself to maximize its probability of being paired with another entity of desired ...
Rohit T P +4 more
openaire +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Simulation-based fitness landscape analysis and optimisation of complex problems
Technological and Economic Development of Economy, 2015 Widespread hard optimisation problems in economics and logistics are characterised by large dimensions, uncertainty and nonlinearity and require more powerful methods of stochastic optimisation that traditional ones. Simulation optimisation is a powerful
Galina Merkuryeva, Vitaly Bolshakov
doaj +1 more source
Interval optimization‐based scheduling of interlinked power, gas, heat, and hydrogen systems
IET Renewable Power Generation, 2021 The combined heat and power (CHP) plant is one of the emerging technologies of gas‐fired units, which plays an important role in reducing environmental pollutants and delivering high energy efficiency.
Nima Nasiri +6 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Ain Shams Engineering Journal, 2020 The growth of demand, the need for economic efficiency and optimal utilisation of electric power networks and the high cost of construction of new power networks result in inevitable challenges, such as overloading and excessive power transfer along ...
Ahmad AL Ahmad, Reza Sirjani
doaj +1 more source
Tactics for improving computational performance of criticality analysis in state estimation
IET Generation, Transmission & Distribution, 2021 Power system state estimation is a needful tool for providing reliable data on the system operating conditions. As such, state estimation requires adequate data redundancy levels, which can be expressed in terms of the degrees of criticalities associated
Vinícius B. Braga Flôr +3 more
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source