Results 81 to 90 of about 5,558,612 (273)

Optimisation Technique For Perfect Pairing

, 2023
Abstract Research focuses on the aspects of finding ideal pairs among ’n’ entities under specified constraints. The entities are assumed to be perfectly logical and possess quantifiable properties only. Each entity given a set of criteria is expected to rate itself to maximize its probability of being paired with another entity of desired ...
Rohit T P, Sasi Gopalan, Sunith V S, Amrutha Dinesh, Varsha Shaheen   +4 more
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Optimisation Techniques for Combining Constraint Solvers

, 1996
In recent years, techniques that had been developed for the combination of unification algorithms for equational theories were extended to combining constraint solvers. These techniques inherited an old deficit that was already present in the ombination of equational theories which makes them rather unsuitable for pratical use: The underlying ...
Kepser, Stephan, Richts, Jörn
openaire   +3 more sources

Optimising Graphical Techniques Applied to Irreversible Tracers

Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies, 2018
Graphical analysis techniques are often applied to positron emission tomography (PET) images to estimate\ud physiological parameters. Patlak analysis is primarily used to obtain the rate constant (Ki) that indicates the\ud transfer of a tracer from plasma to the irreversible compartment and ultimately describes how the tracer\ud binds to the targeted ...
Yasser Alzamil, Yulia Hicks, Xin Yang 0033, Christopher Marshall   +3 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advancements and Optimisation Strategies in Building Integrated Photovoltaic Thermal (BIPVT) Systems [PDF]

Iranian Journal of Electrical and Electronic Engineering
This paper provides an overview of the current innovations in Building Integrated Photovoltaic Thermal Systems. This paper briefly describes varying performance evaluation techniques, optimisation techniques, and the environmental impact and cost ...
Mon Prakash Upadhyay, Arjun Deo, Ajitanshu Vedratnam   +2 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source