Results 81 to 90 of about 353,397 (328)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Interval optimization‐based scheduling of interlinked power, gas, heat, and hydrogen systems

IET Renewable Power Generation, 2021
The combined heat and power (CHP) plant is one of the emerging technologies of gas‐fired units, which plays an important role in reducing environmental pollutants and delivering high energy efficiency.
Nima Nasiri, Ahmad Sadeghi Yazdankhah, Mohammad Amin Mirzaei, Abdolah Loni, Behnam Mohammadi‐Ivatloo, Kazem Zare, Mousa Marzband   +6 more
doaj   +1 more source

Optimisation Technique For Perfect Pairing

, 2023
Abstract Research focuses on the aspects of finding ideal pairs among ’n’ entities under specified constraints. The entities are assumed to be perfectly logical and possess quantifiable properties only. Each entity given a set of criteria is expected to rate itself to maximize its probability of being paired with another entity of desired ...
Rohit T P, Sasi Gopalan, Sunith V S, Amrutha Dinesh, Varsha Shaheen   +4 more
openaire   +1 more source

Fitness Landscape-Based Characterisation of Nature-Inspired Algorithms

, 2013
A significant challenge in nature-inspired algorithmics is the identification of specific characteristics of problems that make them harder (or easier) to solve using specific methods.
Amos, Martyn, Crossley, Matthew, Nisbet, Andy   +2 more
core   +1 more source

AlN/GaN-based MOS-HEMT technology: processing and device results [PDF]

, 2011
Process development of AlN/GaN MOS-HEMTs is presented, along with issues and problems concerning the fabrication processes. The developed technology uses thermally grown Al₂O₃ as a gate dielectric and surface
MacFarlane, D., Taking, S., Wasige, E.
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Tactics for improving computational performance of criticality analysis in state estimation

IET Generation, Transmission & Distribution, 2021
Power system state estimation is a needful tool for providing reliable data on the system operating conditions. As such, state estimation requires adequate data redundancy levels, which can be expressed in terms of the degrees of criticalities associated
Vinícius B. Braga Flôr, Milton B. Do Coutto Filho, Julio C. Stacchini de Souza, Andre A. Augusto   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Convex model predictive control for collision avoidance

IET Control Theory & Applications, 2021
This manuscript proposes a model predictive control for collision avoidance for the regulation problem of deterministic linear systems, which provides a priori guarantees of strong system theoretic properties, such as positive invariance and asymptotic ...
Saša V. Raković, Sixing Zhang, Li Dai, Yanye Hao, Yuanqing Xia   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source