Results 71 to 80 of about 600,362 (302)

A hybrid multiagent approach for global trajectory optimization [PDF]

, 2008
In this paper we consider a global optimization method for space trajectory design problems. The method, which actually aims at finding not only the global minimizer but a whole set of low-lying local minimizers(corresponding to a set of different design
Vasile, M., Vasile, Massimiliano, Locateli, M., VASILE M., Locatelli, Marco   +4 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Constrained Engineering Optimization Algorithm Based on Elite Selection

Journal of Algorithms & Computational Technology, 2014
Many engineering optimization problems can be state as function optimization with constrained, intelligence optimization algorithm can solve these problems well.
Xuesong Yan, Wenjing Luo, Chengyu Hu, Hong Yao, Qinghua Wu   +4 more
doaj   +1 more source

Energy Management of a Grid-Connected Microgrid Based on Linear Programming: A Case Study of Beni Mellal Province [PDF]

E3S Web of Conferences
This article examines the potential benefits for a user or an industrial company in Morocco operating a self-production microgrid, when the injection and sale of surplus local production become possible, notably thanks to the presence of an EMS.
El Habbazi Jaouad, Badii Soufiane, Boudaoud Abdelghani, Aqil Mounaim   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Algorithm optimization for solving crew scheduling problems [PDF]

, 2013
In this paper, we are proposing a methodology to determine the most efficient and least costly way of crew pairing optimization. We are developing a methodology based on algorithm optimization on Eclipse opensource IDE using the Java programming language
Oketch, Christine A.
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Deep Principal Correlated Auto-Encoders With Application to Imaging and Genomics Data Integration

IEEE Access, 2020
In terms of complex diseases like schizophrenia, more and more studies are beginning to treat genetic variants and brain imaging phenotypes as an important factor.
Gang Li, Chao Wang, De-Peng Han, Yi-Pu Zhang, Peng Peng, Vince D. Calhoun, Yu-Ping Wang   +6 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source