Results 21 to 30 of about 19,096,786 (283)
Molecules, 2021 Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang +9 more
doaj +1 more source
Optimization design in single wagon-wheel fuel grain of hybrid rocket motor
FirePhysChem, 2021 The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang +5 more
doaj +1 more source
Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022
Molecules, 2023 At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu +3 more
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Quantization Design for Distributed Optimization [PDF]
, 2015 We consider the problem of solving a distributed optimization problem using a distributed computing platform, where the communication in the network is limited: each node can only communicate with its neighbours and the channel has a limited data-rate. A
Jones, Colin N. +2 more
core +3 more sources
Advances in Metaheuristic Algorithms for Optimal Design of Structures, 2019 Gerhard Venter (gventer_vrand.conl) *Vanderpla(ds Research and Development, bit.1767 S 8th St'reef. Suite 100, Colorado Springs. CO 80906Jaroslaw Sobieszczanski-Sobieski (j.sobieski:_larc.nasa.gov) *A_4SA Lcmgley Research Ce,_terMS 240, Hampton, I:4 ...
Gerhard Venter +1 more
semanticscholar +1 more source
An aerothermodynamic design optimization framework for hypersonic vehicles [PDF]
, 2018 In the aviation field great interest is growing in passengers transportation at hypersonic speed. This requires, however, careful study of the enabling technologies necessary for the optimal design of hypersonic vehicles.
Di Giorgio, Simone +3 more
core +1 more source
Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope
Acta Pharmaceutica Sinica B, 2022 The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma +10 more
doaj +1 more source
Evolutionary Synthesis of HVAC System Configurations: Algorithm Development. [PDF]
, 2008 This paper describes the development of an optimization procedure for the synthesis of novel heating, ventilating, and air-conditioning (HVAC) system configurations. Novel HVAC system designs can be synthesized using model-based optimization methods. The
Angelov, Plamen +4 more
core +3 more sources
Multi-Disciplinary Optimization Design of Axial-Flow Pump Impellers Based on the Approximation Model
Energies, 2020 This study adopts a multi-disciplinary optimization design method based on an approximation model to improve the comprehensive performance of axial-flow pump impellers and fully consider the interaction and mutual influences of the hydraulic and ...
Lijian Shi, Jun Zhu, F. Tang, Chuan Wang
semanticscholar +1 more source
Wiring optimization explanation in neuroscience: What is Special about it? [PDF]
, 2019 This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core +6 more sources