Penghantaran Hesperidin dengan Kombinasi Polimer Alginat-kitosan dalam Matriks Hidrogel Mukoadhesif [PDF]
, 2015 Hesperidin merupakan flavonoid yang berasal dari tanaman jeruk yang dilaporkan memiliki aktivitas antidiabetes. Pemanfaatan hesperidin memiliki keterbatasan karenabioavailabilitasnya yang rendah, sehingga dilakukan modifikasi penghantarannya ke ...
Maryono, M. (Maryono)
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Enhanced Hydrogen Production at Optimum pH for the Recovery Cycle of β-FeOOH. [PDF]
ACS Omega, 2022 Yoon Y +4 more
europepmc +1 more source
Rawatan larut resapan menggunakan penjerap media komposit karbon teraktif, zeolit, batu kapur dan enapcemar sisa kertas [PDF]
, 2019 Kajian ini dijalankan bagi meneroka potensi WPS dan LS untuk menggantikan sebahagian AC dan ZEO dalam penghasilan media komposit baharu. Nisbah optimum AC-WPS (media hidrofobik) adalah 2:2, manakala ZEO-LS (media hidrofilik) adalah 25:15.
A. Rahman, Shahril Effendi
core
The Double pH Optimum of 5'-Nucleotidase of Bull Seminal Plasma
Journal of Biological Chemistry, 1966 Abstract The action of bull seminal plasma 5'-nucleotidase on adenosine 5'-phosphate in the presence of magnesium has one optimum at pH 7.5 to 8.0 and a second at pH 9.1 to 9.3. Only one optimum, at pH 7.5 to 8.0, occurs in the absence of magnesium. The phenomenon of a double pH optimum was independent of the nature of the buffer that was employed.
S J, Levin, O, Bodansky
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Acidic Shift of Optimum pH of Bovine Serum Amine Oxidase upon Immobilization onto Nanostructured Ferric Tannates. [PDF]
Int J Mol Sci, 2022 Rilievo G +12 more
europepmc +1 more source
Residue mutations of xylanase in Aspergillus kawachii alter its optimum pH
Microbiological Research, 2016 Aspergillus kawachii and Aspergillus niger have been traditionally used as molds for commercial microbial fermentation because of their capability to grow in extremely acidic environments and produce acid-stable enzymes. Endo-1,4-β-xylanase cleaves the glycosidic bonds in the xylan backbone, consequently reducing the degree of polymerization of the ...
Qiu, Jin +6 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
PH OF THE TOPICAL DRUG VEHICLE: SELECTING AN OPTIMUM VALUE AND ROLE OF THE BUFFER SYSTEM
Vestnik Dermatologii i Venerologii, 2017 The following three groups of factors must be taken into consideration for selecting an optimum pH value of a topical drug: pharmaceutical, pharmacological and compatibility factors.
A. S. Dukhanin
doaj +1 more source