Results 191 to 200 of about 704,312 (278)

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

A Commentary on "Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway". [PDF]

Neurospine
Xue W, Dai A, Liu Q.
europepmc   +1 more source

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel   +2 more
wiley   +1 more source

Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin's Role in Locomotion, Reinforcement, and Compulsivity. [PDF]

J Neurosci
Robke R, Sansi F, Arbab T, Tunez A, Moore M, Bartsch D, Schönig K, Willuhn I.   +7 more
europepmc   +1 more source

Electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive

The Journal of Physiology, EarlyView.
Abstract figure legend Highlights of the main electrophysiological differences between MDJ neurons that project to the IO and those that do not. IO‐projecting neurons fire rebound spikes and are spontaneously active at higher frequencies. The bottom panel shows the anatomical connectivity of the MDJ with both excitatory and newly discovered inhibitory ...
Stijn Voerman, Xiang Wang, Xiaolu Wang, Laurens W. J. Bosman, Robin Broersen, Chris I. De Zeeuw   +5 more
wiley   +1 more source

The Effect of the Optogenetic Stimulation of Astrocytes on Neural Network Activity in an In Vitro Model of Alzheimer's Disease. [PDF]

Int J Mol Sci
Mitroshina EV, Kalinina EP, Kalyakulina AI, Teplyakova AV, Vedunova MV.   +4 more
europepmc   +1 more source

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Acidosis depolarises parasympathetic respiratory motoneurones in the dorsal motor nucleus of the vagus (DMV) and increases their firing frequency by reducing TWIK‐2 channel conductance. Acidosis also activates astrocytes, which further enhance neuronal excitability through NMDA receptor‐dependent glutamatergic signalling.
Daniel P. de Souza, Renato W. Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho, Davi J. A. Moraes   +4 more
wiley   +1 more source

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway. [PDF]

Neurospine
Ma YH, Chen HY, Wei QS, Peng LZ, Zhang KJ, Deng QW, Wang LJ, Liu Z, Lai BQ, Ding Y, Li G, Jiang B, Lan Y, Zeng X, Zeng YS.   +14 more
europepmc   +1 more source

Channelrhodopsin ion selectivity determines mechanisms and efficacy of optogenetic defibrillation in human atria and ventricles

The Journal of Physiology, EarlyView.
Abstract figure legend A, we used in silico models of human cardiomyocytes and microelectrode recordings on transgenic zebrafish hearts to study electrophysiology during optogenetic perturbations. Specifically, we compared effects of three distinct classes of channelrhodopsins: the cation non‐selective Chlamydomonas reinhardtii channelrhodopsin‐2 (ChR2)
Sophia Ohnemus, Albert Dasí, Ahmed F. Ramadan, Joachim Greiner, Eike M. Wülfers, Matthew R. Stoyek, Linda Tillert, Johannes Vierock, T. Alexander Quinn, Peter Kohl, Patrick M. Boyle, Viviane Timmermann, Franziska Schneider‐Warme   +12 more
wiley   +1 more source

Fetal rat neural progenitor cell transplantation after spinal cord injury improves motor recovery following optogenetic stimulation. [PDF]

Mol Ther
Sánchez-Martín MDM, Giraldo E, Alastrue-Agudo A, López-Mocholi E, Martín-Pérez S, Maninno L, Paniagua Soriano G, Fraga Sánchez AI, Monreal-Trigo J, Terrés-Haro JM, Vidal Beneyto Q, Conesa A, van Niekerk E, Tuszynski M, Moreno-Manzano V.   +14 more
europepmc   +1 more source