Results 201 to 210 of about 704,312 (278)

Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of Mice. [PDF]

ACS Chem Neurosci
Araragi N, Petermann M, Suzuki M, Larkum M, Mosienko V, Bader M, Alenina N, Klempin F.   +7 more
europepmc   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

The effects of locus coeruleus optogenetic stimulation on global spatiotemporal patterns in rats. [PDF]

Imaging Neurosci (Camb)
Anumba N, Kelberman MA, Pan W, Marriott A, Zhang X, Xu N, Weinshenker D, Keilholz S.   +7 more
europepmc   +1 more source

Coiled Coils as a Programmable Platform for Computational Biosensor Design

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Coiled coils provide compact, programmable scaffolds for converting molecular recognition and conformational change into biosensor outputs. Their sequence–structure principles are supported by computational design strategies for tuning affinity, orthogonality, switching, and robustness, enabling biosensors that respond to diverse environmental and ...
Paul Kluge, Faezeh Shabani, Sibylle Gemming, Georg Künze   +3 more
wiley   +1 more source

Optogenetic Stimulation of Ca2+ Influx via Channelrhodopsin CapChR2 in Schwann Cells Promotes Neurite Outgrowth in Co-cultured PC12 Cells: A Neuronal Model. [PDF]

Cureus
Tsutsumi M, Sato-Numata K, Suttinont C, Numata T.   +3 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, Volume 20, Issue 11, Page 2674-2698, November 2026.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Optogenetic stimulation and simultaneous optical mapping of membrane potential and calcium transients in human engineered cardiac spheroids. [PDF]

J Mol Cell Cardiol
Guragain B, Zhang H, Wu Y, Wang Y, Wei Y, Wood GA, Ye L, Walcott GP, Zhang J, Rogers JM.   +9 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, Volume 13, Issue 61, 3 November 2026.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation. [PDF]

PLoS One
Requejo-Mendoza N, Arias-Montaño JA, Gutierrez R.   +2 more
europepmc   +1 more source