Results 31 to 40 of about 704,312 (278)

An inexpensive programmable optogenetic platform for controlled neuronal activation regimens in C. elegans

APL Bioengineering, 2020
In Caenorhabditis elegans, optogenetic stimulation has been widely used to assess neuronal function, control animal movement, or assay circuit responses to controlled stimuli.
Zachary Crawford, Adriana San-Miguel
doaj   +1 more source

Optogenetics stimulates nerve reorganization in the contralesional anterolateral primary motor cortex in a mouse model of ischemic stroke

Neural Regeneration Research, 2022
The anterolateral motor cortex of rodents is an important motor auxiliary area, and its function is similar to that of the premotor area in humans. Activation and inhibition of the contralesional anterolateral motor cortex (cALM) have been shown to have ...
Bei-Yao Gao, Yi-Xing Cao, Peng-Fei Fu, Ying Xing, Dan Liang, Shan Jiang, Yu-Xiao Xie, Min Li   +7 more
doaj   +1 more source

Optogenetic Stimulation of Skeletal Muscles [PDF]

Biophysical Journal, 2014
Numerous neurological diseases lead to paralysis of intact skeletal muscles. Electrical stimulation of these to restore contraction is problematic due to side effects, the lack of cellspecificity and simultaneous activation of antagonist muscles.Optogenetic stimulation of skeletal muscles expressing the light-sensitive cation channel Channelrhodopsin2 (
Brügmann, Tobias, van Bremen, Tobias, Send, Thorsten, Holst, Frank, Schröck, Andreas, Sasse, Philipp   +5 more
openaire   +1 more source

Peripheral optogenetic stimulation induces whisker movement and sensory perception in head-fixed mice

eLife, 2016
We discovered that optical stimulation of the mystacial pad in Emx1-Cre;Ai27D transgenic mice induces whisker movements due to activation of ChR2 expressed in muscles controlling retraction and protraction.
Sunmee Park, Akhil Bandi, Christian R Lee, David J Margolis   +3 more
doaj   +1 more source

Optogenetic Stimulation of Primary Cardiomyocytes Expressing ChR2

Journal of Lasers in Medical Sciences, 2021
Introduction: Non-clinical cardiovascular drug safety assessment is the main step in the progress of new pharmaceutical products. Cardiac drug safety testing focuses on a delayed rectifier potassium channel block and QT interval prolongation, whereas optogenetics is a powerful technology for modulating the electrophysiological properties of excitable ...
Hoda Keshmiri Neghab, Mohammad Hasan Soheilifar, Ali Akbar Saboury, Bahram Goliaei, Jun Hong, Gholamreza Esmaeeli Djavid   +5 more
openaire   +3 more sources

Auditory nerve responses to combined optogenetic and electrical stimulation in chronically deaf mice

, 2023
Objective. Optogenetic stimulation of the auditory nerve offers the ability to overcome the limitations of cochlear implants through spatially precise stimulation, but cannot achieve the temporal precision nor temporal fidelity required for good hearing ...
Ajay, Elise A, Wise, Andrew K, Trang, Ella P, Thompson, Alexander C, Fallon, James B, Grayden, David B, Richardson, Rachael T, Alexander C Thompson, Ella P Trang, Elise A Ajay, James B Fallon, Andrew K Wise, David B Grayden, Rachael T Richardson   +13 more
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Comparison between direct electrical and optogenetic subthalamic nucleus stimulation [PDF]

, 2018
Subthalamic nucleus deep brain stimulation is a treatment for Parkinson’s disease. In this study, a computational model of a plateau-potential generating subthalamic nucleus neuron (Otsuka-model) and a four-state ChR2(H134R) model (Williams-model) are ...
Robrecht Raedt, Thomas Tarnaud, Tanghe, Emmeric, Schoeters, Ruben, Joseph, Wout, Emmeric Tanghe, Tarnaud, Thomas, Wout Joseph, Martens, Luc, Ruben Schoeters, Luc Martens, Raedt, Robrecht   +11 more
core   +1 more source

Single-pulse stimulation of cerebellar nuclei stops epileptic thalamic activity

Brain Stimulation, 2021
Background: Epileptic (absence) seizures in the cerebral cortex can be stopped by pharmacological and optogenetic stimulation of the cerebellar nuclei (CN) neurons that innervate the thalamus.
Oscar H.J. Eelkman Rooda, Lieke Kros, Sade J. Faneyte, Peter J. Holland, Simona V. Gornati, Huub J. Poelman, Nico A. Jansen, Else A. Tolner, Arn M.J.M. van den Maagdenberg, Chris I. De Zeeuw, Freek E. Hoebeek   +10 more
doaj   +1 more source

Behavioral detectability of optogenetic stimulation of inferior temporal cortex varies with the size of concurrently viewed objects

Current Research in Neurobiology, 2023
We have previously demonstrated that macaque monkeys can behaviorally detect a subtle optogenetic impulse delivered to their inferior temporal (IT) cortex. We have also shown that the ability to detect the cortical stimulation impulse varies depending on
Rosa Lafer-Sousa, Karen Wang, Reza Azadi, Emily Lopez, Simon Bohn, Arash Afraz   +5 more
doaj   +1 more source

Nonlinear response characteristics of neural networks and single neurons undergoing optogenetic excitation

Network Neuroscience, 2020
Optogenetic stimulation has become the method of choice for investigating neural computation in populations of neurons. Optogenetic experiments often aim to elicit a network response by stimulating specific groups of neurons. However, this is complicated
Jannik Luboeinski, Tatjana Tchumatchenko
doaj   +1 more source