Results 11 to 20 of about 704,312 (278)
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
EMBO Molecular Medicine, 2021 Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants of the red‐light‐activated channelrhodopsin (ChR)
Burak Bali +6 more
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Real-time electrochemical recording of dopamine release under optogenetic stimulation.
PLoS ONE, 2014 Dopaminergic PC12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. Optogenetic stimulation of channelrhodopsin-2 provides high spatial and temporal precision for selective stimulation as a ...
Wen-Tai Chiu +6 more
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Portable closed-loop optogenetic stimulation device
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016 This paper presents a closed-loop optogenetic stimulation device to achieve online modulation of neurons. The device is designed to be mountable on small rodents in pre-clinical settings. Considering the size of rodents and the need for portability, a single-piece self-contained device is developed which allows real-time photostimulation based on ...
Epsy S. Edward +3 more
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Chronic Optogenetic Stimulation in Freely Moving Rodents
, 2020 In vivo optogenetic strategies have been fundamental for the investigation of how neural circuits relate to behavior. While short-term experimental procedures are typically used in such studies, chronic stimulation during behavioral sessions has been largely unexplored.
Moulin, Thiago,
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Frontiers in Neuroscience, 2022 Efficient interhemispheric integration of neural activity between left and right primary motor cortex (M1) is critical for inter-limb motor control. We employed optogenetic stimulation to establish a framework for probing transcallosal M1–M1 interactions
Christian Stald Skoven +10 more
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Frontiers in Physiology, 2019 Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to ...
Philipp Sasse +7 more
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Closed-loop functional optogenetic stimulation [PDF]
Nature Communications, 2018 Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved ...
Shriya S. Srinivasan +4 more
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LITOS: a versatile LED illumination tool for optogenetic stimulation [PDF]
, 2022 Optogenetics has become a key tool to manipulate biological processes with high spatio-temporal resolution. Recently, a number of commercial and open-source multi-well illumination devices have been developed to provide throughput in optogenetics ...
Paolo Armando Gagliardi +11 more
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A STIMulating journey into optogenetic engineering [PDF]
Cell Calcium, 2020 Genetically-encoded calcium actuators (GECAs) stemmed from STIM1 have enabled optical activation of endogenous ORAI1 channels in both excitable and non-excitable tissues. These GECAs offer new non-invasive means to probe the structure-function relations of calcium channels and wirelessly control the behavior of awake mice.
Guolin Ma, Yubin Zhou
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Optogenetic Stimulation of the Auditory Nerve [PDF]
Journal of Visualized Experiments, 2014 Direct electrical stimulation of spiral ganglion neurons (SGNs) by cochlear implants (CIs) enables open speech comprehension in the majority of implanted deaf subjects(1-) (6). Nonetheless, sound coding with current CIs has poor frequency and intensity resolution due to broad current spread from each electrode contact activating a large number of SGNs ...
Victor H, Hernandez +6 more
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