Results 91 to 100 of about 2,176,373 (353)

Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids [PDF]

, 2020
Ionic liquids are salts used in a variety of industrial processes, and being relatively non-volatile, are proposed as environmentally-friendly replacements for existing volatile liquids.
Abdelghany, Tarek M., Blain, Peter G., Dunn, Michael P., Lanyon, Clare, Leitch, Alistair C., Strnad, Pavel, Wright, Matthew C., Young, Gregory   +7 more
core   +2 more sources

Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles

International Journal of Molecular Sciences, 2018
Resveratrol is a naturally occurring polyphenol that provides several health benefits including cardioprotection and cancer prevention. However, its biological activity is limited by a poor bioavailability when taken orally.
Rebeca Peñalva, J. Morales, C. J. González-Navarro, E. Larrañeta, G. Quincoces, I. Peñuelas, J. Irache   +6 more
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism

Drug Delivery, 2021
The intestinal capillary pathway is the most common way to absorb oral drugs, but for drugs with poor solubility and permeability and high first-pass metabolism, this pathway is very inefficient.
Xinran Wang, Cai Zhang, Ning Han, Juyuan Luo, Shuofeng Zhang, Chunguo Wang, Zhanhong Jia, Shouying Du   +7 more
doaj   +1 more source

Effect of weathering product assemblages on Pb bioaccessibility in mine waste: implications for risk management [PDF]

, 2013
General assessments of orebody types and associated mine wastes with regards to their environmental signature and human health hazards are needed to help managing present and historical mine waste facilities.
Cave, Mark R., Palumbo-Roe, Barbara, Wagner, Doris, Wragg, Joanna   +3 more
core   +2 more sources

Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Chemistry Central Journal, 2018
BackgroundDoxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors.
N. Ahmad, R. Ahmad, M. Alam, F. Ahmad
semanticscholar   +1 more source

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features

Advanced Healthcare Materials, EarlyView.
This study characterizes the presence of microplastics in human normal gastric, para‐tumor, and gastric tumor tissue and confirms the association between microplastic exposure and lymph node metastasis in gastric cancer. This study explores the transcriptomic changes induced by microplastic exposure, laying the foundation for further investigation into
Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Xiyuan Han, Anqiang Wang   +13 more
wiley   +1 more source

Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability

Pharmaceutics, 2019
Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and is prone to extensive liver degradation, it suffers from poor bioavailability after oral administration.
Ahmed Khames
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. [PDF]

, 2011
Backbone N-methylation is common among peptide natural products and has a substantial impact on both the physical properties and the conformational states of cyclic peptides.
Bauman, Jonathan N, Gelev, Vladimir M, Jacobson, Matthew P, Kalgutkar, Amit S, Leung, Siegfried SF, Linington, Roger G, Liras, Spiros, Lokey, R Scott, Mathiowetz, Alan M, McEwen, Cayla M, Price, David A, Rand, Arthur C, Renzelman, Chad M, Rezai, Taha, Turner, Rushia A, White, Tina R, Zhang, Yizhong   +16 more
core   +1 more source