Results 261 to 270 of about 2,176,373 (353)

Enhanced Oral Bioavailability and Biodistribution of Voriconazole through Zein-Pectin-Hyaluronic Acid Nanoparticles. [PDF]

ACS Appl Mater Interfaces
Fin MT, Diedrich C, Machado CS, da Silva LM, Tartari APS, Zittlau IC, Peczek SH, Mainardes RM.   +7 more
europepmc   +1 more source

Antidiabetic Potential of Ligands from NEIST_PMIB_06, Bacterium Associated with Hawaijar (Fermented Soy Food): Insight from in Vitro and in Silico Studies

ChemFoodChem, EarlyView.
ABSTRACT In this study, a bacterium (NEIST_PMIB_06) was isolated from Hawaijar, a fermented soy food from Manipur, Northeast India. The bacterium was inoculated and incubated to isolate bioactive compounds. Liquid‐liquid extraction was performed to obtain extracts (cell‐free and cell‐based), and their efficacy was evaluated.
A Ibeyaima, Hiranmoy Barman, Prasenjit Manna   +2 more
wiley   +1 more source

Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. [PDF]

PLoS One
Ashar F, Mohammed AAS, Selvamuthukumar S.   +2 more
europepmc   +1 more source

Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound

Chemistry – A European Journal, EarlyView.
ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske, Guanhong Bu, Máté Erdélyi, Jan Kihlberg, Tamir Gonen, Emma Rova Danelius   +5 more
wiley   +1 more source

Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability. [PDF]

Pharmaceutics
Koch N, Bourcy Q, Jennotte O, Chiap P, Lechanteur A, Cardot JM, Evrard B.   +6 more
europepmc   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems. [PDF]

Sci Rep
Sato VH, Sato H, Sangfuang M, Nontakham J, Junyaprasert VB, Teeranachaideekul V, Morakul B.   +6 more
europepmc   +1 more source

Enhanced oral bioavailability of two Cistanche polysaccharides in acteoside: an in-depth analysis of intestinal flora, short-chain fatty acids, and pharmacokinetic regulation. [PDF]

Front Nutr
Lian J, Zhang Y, Dong K, Shi J, Zhang F, Shan G, Liu P, Wang N, Jia T.   +8 more
europepmc   +1 more source

Enhanced oral bioavailability of cannabidiol by flexible zein nanoparticles: in vitro and pharmacokinetic studies. [PDF]

Front Nutr
Nie Y, Kong Y, Peng J, Sun J, Fan B.
europepmc   +1 more source

Water in nigella oil microemulsion for enhanced oral bioavailability of linagliptin. [PDF]

Drug Deliv Transl Res
Eid RK, Arafa MF, El Maghraby GM.
europepmc   +1 more source