Results 191 to 200 of about 587,078 (311)

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Editorial: Challenges to research on oral potentially malignant disorders and oral cancer. [PDF]

Front Oncol
Rodríguez-Archilla A, Gaitán-Cepeda LA.   +1 more
europepmc   +1 more source

Experience with oral morphine for cancer pain relief

, 1989
S. Vijayaram, Krishna P. Bhargava, Ramamani, Chandrasekhar, Sudharshan, Roshni Heranjal, Bridget Lobo   +6 more
openalex   +1 more source

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Protracted oral etoposide in epithelial ovarian cancer: a phase II study in patients with relapsed or platinum-resistant disease [PDF]

, 1994
Michel Seymour, JL Mansi, CJ Gallagher, ME Gore, PG Harper, TRJ Evans, PM Edmonds, ML Slevin   +7 more
openalex   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

Unveiling Oral Cancer Epidemiology in Pakistan: Insights From a Case-Control Study. [PDF]

Glob Health Epidemiol Genom
Shabir A, Kazmi S, Rashid MU, Mubeen I, Jamshed A, Hussain SR, Malkani N.   +6 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Enzymological studies on oral cancer

, 1980
Yutaka Okada, Fumihiro Ohsaka, Soichiro Asanami, Tomomi Sakurada   +3 more
openalex   +2 more sources

Oral complications of cancer. [PDF]

, 1991
F. Calman, J Langdon
openalex   +1 more source