Results 81 to 90 of about 22,234 (251)

The impact and cost-effectiveness of controlling cholera through the use of oral cholera vaccines in urban Bangladesh: A disease modeling and economic analysis. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Cholera remains an important public health problem in major cities in Bangladesh, especially in slum areas. In response to growing interest among local policymakers to control this disease, this study estimated the impact and cost ...
Ashraful Islam Khan, Ann Levin, Dennis L Chao, Denise DeRoeck, Dobromir T Dimitrov, Jahangir A M Khan, Muhammad Shariful Islam, Mohammad Ali, Md Taufiqul Islam, Abdur Razzaque Sarker, John D Clemens, Firdausi Qadri   +11 more
doaj   +1 more source

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Efficacy and Safety of Cholera Vaccines

Биопрепараты: Профилактика, диагностика, лечение, 2018
Cholera is an acute diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and O139 serogroups. It still remains a major  global healthcare problem.
A. A. Goryaev, L. V. Sayapina, Yu. I. Obukhov, V. P. Bondarev   +3 more
doaj   +1 more source

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Understanding the Enigmatic Dance of Immune‐Mediated Viral Infections and Their Pathogenetic Mechanisms

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut, Tuba Çiğdem Oğuzoğlu   +1 more
wiley   +1 more source

Construction and evaluation of V. cholerae O139 mutant, VCUSM21P, as a safe live attenuated cholera vaccine. [PDF]

PLoS ONE, 2014
Cholera is a major infectious disease, affecting millions of lives annually. In endemic areas, implementation of vaccination strategy against cholera is vital.
Chandrika Murugaiah, Nik Zuraina Nik Mohd Noor, Shyamoli Mustafa, Ravichandran Manickam, Lalitha Pattabhiraman   +4 more
doaj   +1 more source

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

Cholera in Haiti:reproductive numbers and vaccination coverage estimates [PDF]

, 2013
Cholera reappeared in Haiti in October, 2010 after decades of absence. Cases were first detected in Artibonite region and in the ensuing months the disease spread to every department in the country.
Morris, J Glenn, Mukandavire, Zindoga, Smith, David L   +2 more
core   +2 more sources

Effectiveness and economic analysis of the whole cell/recombinant B subunit (WC/rbs) inactivated oral cholera vaccine in the prevention of traveller's diarrhoea

BMC Infectious Diseases, 2009
Background Nowadays there is a debate about the indication of the oral whole-cell/recombinant B-subunit cholera vaccine (WC/rBS) in traveller's diarrhoea. However, a cost-benefit analysis based on real data has not been published.
Diez-Diaz Rosa, Reina Emilia, Calvo Maria J, Garcia-Fortea Pedro, López-Gigosos Rosa, Plaza Elena   +5 more
doaj   +1 more source

Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Cholera is an acute voluminous dehydrating diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and occasionally O139. A growing body of evidence indicates that immune responses targeting the O-specific polysaccharide (OSP) of V.
Kamrul Islam, Motaher Hossain, Meagan Kelly, Leslie M Mayo Smith, Richelle C Charles, Taufiqur Rahman Bhuiyan, Pavol Kováč, Peng Xu, Regina C LaRocque, Stephen B Calderwood, Jakub K Simon, Wilbur H Chen, Douglas Haney, Michael Lock, Caroline E Lyon, Beth D Kirkpatrick, Mitchell Cohen, Myron M Levine, Marc Gurwith, Jason B Harris, Firdausi Qadri, Edward T Ryan   +21 more
doaj   +1 more source