Results 91 to 100 of about 1,518,868 (239)

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Real-life safety of peanut oral immunotherapy: Results from a French multicenter observational study

Journal of Allergy and Clinical Immunology: Global
Background: Peanut oral immunotherapy (POIT) has been widely used in France for more than 10 years. However, the overall “real-life” safety of POIT has not been evaluated to date.
Elodie Michaud, MD, Flore Amat, MD, PhD, Dr Habil, Céline Lambert, MSc, Amandine Divaret-Chauveau, PhD, Antoine Deschildre, Pr, A. Nemni, M. Voidey, T. Moraly, P. Bierme, D. Sabouraud, L. Couderc, D. Caimmi, A. Dupré Latour   +12 more
doaj   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Safer oral immunotherapy with very low-dose introduction for pediatric hen’s egg allergy

Journal of Allergy and Clinical Immunology: Global
Background: Adverse events could be a barrier to implementing oral immunotherapy (OIT) in children with hen’s egg (HE) allergy, highlighting the need for safer OIT methods.
Fumi Ishikawa, MD, Yumiko Miyaji, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Mami Shimada, MD, Tomoyuki Kiguchi, MD, Seiko Hirai, MD, Yuri Endo Kram, MD, Kazuma Takada, MD, Kyoko Noguchi, MD, Yusuke Inuzuka, MD, Kenji Toyokuni, MD, PhD, Mayako Saito-Abe, MD, PhD, Miori Sato, MD, Shigenori Kabashima, MD, PhD, Kyongsun Pak, PhD, Eisuke Inoue, PhD, Tatsuki Fukuie, MD, PhD, Yukihiro Ohya, MD, PhD   +17 more
doaj   +1 more source

Current Insights into Immunotherapy Approaches for Food Allergy

ImmunoTargets and Therapy, 2021
Jessica D Macdougall,1 A Wesley Burks,1 Edwin H Kim2 1Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA; 2Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC ...
Macdougall JD, Burks AW, Kim EH
doaj  

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Shellfish Allergy Immunotherapy: Are We Moving Forward?

Allergies
Shellfish allergy is among the most common food allergies (FAs) worldwide and represents a severe immunoglobulin E (IgE)-mediated FA with tropomyosin functioning as the predominant pan-allergen.
Lucio H. T. Fung, Ho Lam Yeung, Chun Wai Lim, Shan Jiang, Nicki Y. H. Leung, Patrick S. C. Leung, Ting Fan Leung, Christine Y. Y. Wai   +7 more
doaj   +1 more source

Exploring Health-Related Quality of Life Burden in Peanut Allergy and the Potential Benefit of Oral Immunotherapy: Estimation of Health State Utility Values for Children and Adolescents and Their Caregivers

Patient Preference and Adherence, 2022
Katy Gallop,1 Sarah Acaster,1 Jane de Vries,2 Richard Browne,2 Robert Ryan,2 Sarah Baker,3 George Du Toit4 1Acaster Lloyd Consulting Ltd, London, UK; 2Aimmune Therapeutics, London, UK; 3Anaphylaxis Campaign, Farnborough, UK; 4Department of Paediatric ...
Gallop K, Acaster S, de Vries J, Browne R, Ryan R, Baker S, Du Toit G   +6 more
doaj  

Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis

Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease, clinically characterised by symptoms of esophageal dysfunction and histologically by eosinophilic infiltration of its wall.
Justyna Przybyszewska, Zbigniew Bartuzi, Andrzej Kuźmiński   +2 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source