Results 71 to 80 of about 1,518,868 (239)

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

An international survey of oral medicine practice: proceedings from the 5th World Workshop in Oral Medicine

, 2011
Objectives: (i) To define the current state of oral medicine clinical practice internationally, and (ii) to make recommendations for future modeling of the practice of oral medicine.
ET Stoopler, Greenberg, M. S., M. Arvind, Thongprasom, K., Q. Liu, M Arvind, M. T. Brennan, H. Liu, Stoopler, E. T., AA Garfunkel, K Thongprasom, Garfunkel, A. A., Shirlaw, P., Arvind, M., J. Gibson, C. Bez, MS Greenberg, De Rossi, S., A. A. Garfunkel, Gibson, J., P Shirlaw, Garfunkel, A.A., E. T. Stoopler, Liu, H., Brennan, M. T., Greenberg, M.S., Lo Russo, L., Liu, Q., Wang, Q., G. De Rossi, C Bez, Q. Wang, H Liu, Stoopler, E.T., Q Liu, S De Rossi, M. S. Greenberg, LO RUSSO, LUCIO, J Gibson, K. Thongprasom, Bez, C., Q Wang, L Lo Russo, P. Shirlaw, Brennan, M.T., MT Brennan   +45 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Oral manifestations caused by the linear IgA disease

, 2004
La enfermedad por depósito lineal de IgA o enfermedad IgA lineal (EAL) es un proceso mucocutaneo crónico e infrecuente de origen autoinmune, caracterizado por depósitos lineales de IgA a lo largo de la membrana basal.
Martínez-Sahuquillo Márquez, Ángel
core   +1 more source

Routinely Used and Emerging Diagnostic and Immunotherapeutic Approaches for Wheat Allergy

Biomedicines
Wheat, a component of the staple diet globally, is a common food allergen in children. The symptoms of wheat allergy (WA) range from skin rash to shortness of breath, significantly impairing quality of life.
Wanqi Zheng, Christine Yee Yan Wai, Jason Ka Chun Sit, Nam Sze Cheng, Christy Wing Man Leung, Ting Fan Leung   +5 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Studies investigating peripherial blood derived cells that express the high affinity receptor for immunoglobulin E (FceRI) in allergic disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Improving Safety in Food Allergen-Specific Oral Immunotherapy

Applied Sciences
Food allergies are becoming more common globally. The strict elimination diet, as the main approach so far, has a negative impact on different areas of the lives of children suffering from food allergies, as well as on their caregivers.
Iva Mrkić Kobal, Milan Jurić, Helena Munivrana Škvorc, Adrijana Miletić Gospić, Andrija Miculinić, Davor Plavec   +5 more
doaj   +1 more source