Results 11 to 20 of about 2,548 (213)

Heat-treated egg allergens show lower basophil activation: A path toward safer oral immunotherapy. [PDF]

Pediatr Allergy Immunol
Abstract Background Oral immunotherapy (OIT) is a promising approach for treating IgE‐mediated food allergy, but safety concerns limit its use. Heat‐denaturation of food allergens may reduce allergic reactions by lowering IgE binding. Here, we examined how heat‐induced structural changes in egg allergens affected basophil activation in egg‐allergic ...
Paolucci M, Breiding M, Dietrich M, Meyer JG, Duda A, Köhli A, Lang CCV, Agah S, Wuenschmann S, Eyer K, Kündig TM, Trück J, Johansen P.   +12 more
europepmc   +2 more sources

Oral immunotherapy for cow’s milk allergy in children: a systematic review and meta-analysis [PDF]

Frontiers in Immunology
ObjectiveCow’s milk allergy (CMA) is one of the most common causes of food allergies (FA) in children. There have been studies on the use of immunotherapy in cow’s milk protein allergy, with oral immunotherapy (OIT) being the most extensively researched.
Yan Wang, Yan Wang, Shunli Liu, Shunli Liu, Meizhu Lu, Meizhu Lu, Jingyu Guo, Jingyu Guo, Can Lv, Can Lv, Lan Huang, Lan Huang   +11 more
doaj   +2 more sources

Risk factors for discontinuing oral immunotherapy in children with persistent cow milk allergy [PDF]

Immunity, Inflammation and Disease, 2022
Background There are no universally accepted criteria for discontinuing milk oral immunotherapy (MOIT) in patients with persistent cow milk allergy (CMA) and little data are available on predictive risk factors for dropping out from oral immunotherapy ...
Elisa Benelli, Andrea Trombetta, Laura Badina, Stefanny Andrade, Giulia Zamagni, Antonio Prisco, Eugenio Traini, Egidio Barbi, Irene Berti   +8 more
doaj   +2 more sources

Omalizumab effectiveness in patients with a previously failed oral immunotherapy for severe milk allergy [PDF]

Immunity, Inflammation and Disease, 2022
Background Some studies addressed the issue of omalizumab (OML) effectiveness in children starting their first oral immunotherapy (OIT) attempt but no study investigated the possible role of OML in the setting of patients with persisting milk allergy ...
Laura Badina, Beatrice Belluzzi, Sarah Contorno, Benedetta Bossini, Elisa Benelli, Egidio Barbi, Irene Berti   +6 more
doaj   +2 more sources

Safer oral immunotherapy with very low-dose introduction for pediatric hen’s egg allergy [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Adverse events could be a barrier to implementing oral immunotherapy (OIT) in children with hen’s egg (HE) allergy, highlighting the need for safer OIT methods.
Fumi Ishikawa, MD, Yumiko Miyaji, MD, PhD, Kiwako Yamamoto-Hanada, MD, PhD, Mami Shimada, MD, Tomoyuki Kiguchi, MD, Seiko Hirai, MD, Yuri Endo Kram, MD, Kazuma Takada, MD, Kyoko Noguchi, MD, Yusuke Inuzuka, MD, Kenji Toyokuni, MD, PhD, Mayako Saito-Abe, MD, PhD, Miori Sato, MD, Shigenori Kabashima, MD, PhD, Kyongsun Pak, PhD, Eisuke Inoue, PhD, Tatsuki Fukuie, MD, PhD, Yukihiro Ohya, MD, PhD   +17 more
doaj   +2 more sources

Milk Ladder Efficacy and Safety in IgE-Mediated Cow's Milk Allergy: A Systematic Review and Meta-Analysis of Controlled Studies. [PDF]

Clin Transl Allergy
ABSTRACT Background Milk ladder (ML) is considered a potential therapeutic option for managing cow’s milk allergy (CMA). Although the ML was initially developed to reintroduce cow's milk into the diet for individuals with non‐IgE mediated CMA, it has also recently been used in IgE‐mediated CMA. Objective To perform a systematic review and meta‐analysis
Cuomo B, Verga MC, D'Auria E, Miraglia Del Giudice M, Anania C, Decimo F, Giannì G, Indirli GC, Manca E, Mondì F, Nosratian V, Pendezza E, Sartorio MUA, Calvani M.   +13 more
europepmc   +2 more sources

Successful Oral Immunotherapy (OIT) Due to Anti-IgE Protection. [PDF]

J Clin Med
Background/Objectives: Oral immunotherapy with peanut protein powder is difficult to initiate in patients with a very low reactivity threshold to peanuts. For this specific group, an add-on treatment with omalizumab (anti-IgE monoclonal antibody) is helpful to tolerate the initial steps.
Yoosefi Moridani M, Lau S, Beyer K.
europepmc   +3 more sources

The safety and efficacy of oral immunotherapy compared to epicutaneous immunotherapy in peanut allergen desensitisation amongst the paediatric cohort—a narrative review [PDF]

Frontiers in Allergy
Peanut allergies result from a type 1 hypersensitivity reaction, with a prevalence of approximately 1% in children under 5 years of age. The allergens that instigate this reaction are the peanut proteins (Ara h 1–Ara h 8) for which IgE antibodies are ...
Ehtesam A. Chowdhury, Olivia C. Jadeja
doaj   +2 more sources

Sublingual (SLIT) versus oral immunotherapy (OIT) for food allergy. [PDF]

Curr Allergy Asthma Rep, 2014
Food allergy is a common condition for which the only currently approved treatments are avoidance of the allergenic food and the administration of emergency medications upon accidental exposure. Over the past 10 years, significant advances have been made in the field of food immunotherapy, with efforts focusing on allergen exposure via the oral mucosa.
McGowan EC, Wood RA.
europepmc   +4 more sources

Preclinical evaluation of alternatives to oral immunotherapy for food allergies

Frontiers in Allergy, 2023
The increasing food allergy incidence has led to significant interest in developing therapies for allergic diseases. Oral allergen-specific immunotherapy (OIT) is a recently FDA-approved therapeutic to treat peanut allergies.
Brandi T. Johnson-Weaver
doaj   +1 more source