Results 81 to 90 of about 2,548 (213)

Immunotherapy for cow's milk allergy

Human Vaccines & Immunotherapeutics, 2017
Oral immunotherapy (OIT) is used regularly for young children with cow's milk (CM) allergy and has been shown to be effective in several studies. However, adverse events occur frequently during OIT.
Shoichiro Taniuchi, Masaya Takahashi, Kazukiko Soejima, Yasuko Hatano, Hirotaka Minami   +4 more
doaj   +1 more source

Lung transplantation: Chronic allograft dysfunction and establishing immune tolerance [PDF]

, 2014
Despite significant medical advances since the advent of lung transplantation, improvements in long-term survival have been largely unrealized. Chronic lung allograft dysfunction, in particular obliterative bronchiolitis, is the primary limiting factor ...
Gracon, Adam S.A., Wilkes, David S.
core   +1 more source

Successful sublingual immunotherapy for severe egg allergy in children: a case report

Allergy, Asthma & Clinical Immunology, 2021
Background Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy.
Nagatoshi Sagara, Satoshi Fujita, Ryohei Suzuki, Akiko Aota, Kenichi Akashi, Toshio Katsunuma   +5 more
doaj   +1 more source

A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals

EClinicalMedicine, 2019
Background: As there is limited data on the sustainability of desensitization of multifood-oral immunotherapy (multifood-OIT), we conducted a multisite multifood-OIT study to compare the efficacy of successful desensitization with sustained dosing vs ...
Sandra Andorf, Natasha Purington, Divya Kumar, Andrew Long, Katherine L. O'Laughlin, Scott Sicherer, Hugh Sampson, Antonella Cianferoni, Terri Brown Whitehorn, Daniel Petroni, Melanie Makhija, Rachel G. Robison, Michelle Lierl, Stephanie Logsdon, Manisha Desai, Stephen J. Galli, Efren Rael, Amal Assa'ad, Sharon Chinthrajah, Jacqueline Pongracic, Jonathan M. Spergel, Jonathan Tam, Stephen Tilles, Julie Wang, Kari Nadeau   +24 more
doaj   +1 more source

Practical challenges in oral immunotherapy resolved through patient-centered care

Allergy, Asthma & Clinical Immunology, 2021
Oral immunotherapy (OIT) is now widely recognized as a valid option for the management of IgE-mediated food allergies. However, in real-life practice, OIT can lead to a variety of unique situations where the best course of action is undetermined.
François Graham, Douglas P. Mack, Philippe Bégin   +2 more
doaj   +1 more source

Safety of Food Oral Immunotherapy: What We Know, and What We Need to Learn. [PDF]

, 2019
Oral immunotherapy (OIT) for food allergy entails a risk of adverse reactions, including anaphylaxis. This safety concern is the major barrier for OIT to become a therapeutic option in clinical practice.
Adrianna Machinena, Montserrat Alvaro-Lozano, Montserrat Fernandez-Rivas, Paloma Jaqueti, Sonia Vázquez-Cortés, Stefania Arasi   +5 more
core   +1 more source

Nanoparticulate adjuvants and delivery systems for allergen immunotherapy [PDF]

, 2012
In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of allergic diseases. However, current allergen immunotherapy shows limitations concerning the long-term efficacy
Esparza, I. (Irene), Ferrer, M. (Marta), Gamazo, C. (Carlos), Irache, J.M. (Juan Manuel), Sanz, M.L. (María Luisa), Souza, J. (Juliana) de   +5 more
core   +1 more source

Update on oral immunotherapy for egg allergy

Human Vaccines & Immunotherapeutics, 2017
Oral immunotherapy (OIT) is an emerging treatment of IgE-mediated egg allergy. In the past decade, a multitude of studies have assessed the potential for egg OIT to induce clinical desensitization.
François Graham, Natacha Tardio, Louis Paradis, Anne Des Roches, Philippe Bégin   +4 more
doaj   +1 more source

Debates in Allergy Medicine: Does oral immunotherapy shorten the duration of milk and egg allergy? The pro argument

World Allergy Organization Journal, 2018
The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut.
Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro, Lamia Dahdah   +4 more
doaj   +1 more source

Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies

European Journal of Immunology, Volume 55, Issue 12, December 2025.
Murine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical ...
Yuka Nagata, Ryo Suzuki
wiley   +1 more source