Results 101 to 110 of about 2,246,271 (345)

Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma [PDF]

, 2017
Background: This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbationprone severe asthma.
Brusselle, Guy, Dauwe, Kenny, Deschaght, Pieter, Deschepper, Ellen, Joos, Guy, Jordens, Paul, Lopes dos Santos Santiago, Guido, Vaneechoutte, Dries, Vaneechoutte, Mario, Verhofstede, Chris   +9 more
core   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Circadian Disruption and Metabolic Disease: Findings from Animal Models [PDF]

, 2010
Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one.
Arble, Deanna M., Bass, Joseph, Ramsey, Kathryn Moynihan, Turek, Fred W.   +3 more
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Candida albicans-induced ubiquitination of EGFR reveals novel host–fungal interaction pathways

mBio
Candida albicans causes severe mucosal and systemic infections, with hypha formation playing a key role in its virulence. Hyphal invasion via endocytosis is mediated predominantly through interactions between Als3p and the epidermal growth factor ...
Léa Lortal, James S. Griffiths, Emily L. Priest, Alexander Kempf, Olivia K. A. Paulin, Nicole O. Ponde, Antzela Tsavou, Don N. Wickramasinghe, Andrew Donkin, Claire M. Lyon, Olivia W. Hepworth, Jonathan P. Richardson, Julian R. Naglik   +12 more
doaj   +1 more source

Evidence for Proline Utilization by Oral Bacterial Biofilms Grown in Saliva

Frontiers in Microbiology, 2021
Within the mouth bacteria are starved of saccharides as their main nutrient source between meals and it is unclear what drives their metabolism. Previously oral in vitro biofilms grown in saliva have shown proteolytic degradation of salivary proteins and
Leanne M. Cleaver, Rebecca V. Moazzez, Guy H. Carpenter   +2 more
doaj   +1 more source

Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment

International Journal of Molecular Sciences, 2022
The skin, oral cavity, digestive and reproductive tracts of the human body harbor symbiotic and commensal microorganisms living harmoniously with the host.
M. Di Stefano, A. Polizzi, S. Santonocito, A. Romano, T. Lombardi, G. Isola   +5 more
semanticscholar   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Oral Microbiome Stamp in Alzheimer’s Disease

Pathogens
Recent studies have suggested that periodontal disease and alterations in the oral microbiome may be associated with cognitive decline and Alzheimer’s disease (AD) development.
A. Issilbayeva, Aiym Kaiyrlykyzy, E. Vinogradova, Zharkyn Jarmukhanov, S. Kozhakhmetov, Aliya Kassenova, M. Nurgaziyev, N. Mukhanbetzhanov, Dinara Alzhanova, Gulnaz Zholdasbekova, S. Askarova, A. Kushugulova   +11 more
semanticscholar   +1 more source

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

JCI Insight, 2021
In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact ...
J. Haran, E. Bradley, A. Zeamer, Lindsey Cincotta, Marie-Claire Salive, P. Dutta, S. Mutaawe, O. Anya, Mario Meza-Segura, A. Moormann, D. Ward, B. McCormick, V. Bucci   +12 more
semanticscholar   +1 more source