Results 111 to 120 of about 1,752,430 (254)

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Oral Microbiota and Clinical Outcomes in Allogenic Hematopoietic Stem Cell Transplantation: A Systematic Review

Microorganisms
In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), emerging evidence suggests that the oral microbiota may serve as a predictive biomarker.
Jefferson Luiz da Silva, Alexandre Soares Ferreira Junior, Danielle Amanda Niz Alvarez, Larissa da Silva Souza, Luiza Dias Machado, Sarah Cantrell, Nelson Jen An Chao, Gislane Lelis Vilela de Oliveira   +7 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Diversity analysis of oral and gut microbiota in osteoporotic rats.

PLoS ONE
The oral and gut microbiota had been shown to control bone metabolism and have a strong correlation with osteoporosis. However, to reveal the oral and gut bacteria characteristics in osteoporosis, further studies are still needed to investigate the ...
Mingzhu Chen, Zihan Liao, Zhenjin Yang, Yanjie Li, Liya Ma, Jiangtian Hu   +5 more
doaj   +1 more source

oral microbiota and pathogenesis of systemic disease: is there an involvement?

, 2023
noneBackground:i microambienti distinti in diversi siti della cavità orale ospitano comunità microbiche uniche, che sono regolate attraverso sofisticati sistemi di segnalazione e da fattori ambientali e dell’ospite.
PALUDETTO, GIULIA
core  

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

A bibliometric and visualized in oral microbiota and cancer research from 2013 to 2022

Discover Oncology
Numerous studies have highlighted the implication of oral microbiota in various cancers. However, no bibliometric analysis has been conducted on the relationship between oral microbiota and cancer.
Zhiyu Gu, Yunkun Liu
doaj   +1 more source

Whole-Genome Metagenomic Analysis of the Oral Microbiota in Patients with Obstructive Sleep Apnea Comorbid with Major Depressive Disorder [PDF]

Jing Ye,1,2 Yunhui Lv,2 Hui Xie,3 Kun Lian,4 Xiufeng Xu1 1Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Sleep Medicine Center, The First People’s Hospital of Yunnan ...
Lian K, Xie H, Lv Y, Xu X, Ye J
core