Results 41 to 50 of about 1,752,430 (254)

An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tract of rats [PDF]

, 2012
BACKGROUND: Horizontal gene transfer through natural transformation of members of the microbiota of the lower gastrointestinal tract (GIT) of mammals has not yet been described.
Raddadi Noura, Nielsen KM, Traavik T, Terje Traavik, Brusetti Lorenzo, Averhoff, Beate, Nordgård Lise, Beate Averhoff, Nordgård, Lise, Noura Raddadi, Brusetti L, Nielsen, Kaare Magne, Kaare Magne Nielsen, Traavik, Terje, Nielsen Kaare, Traavik Terje, Lorenzo Brusetti, Raddadi, Noura, Averhoff B, Brusetti, Lorenzo, Averhoff Beate, Nordgård L, Lise Nordgard   +22 more
core   +1 more source

Alterations of oral and gut viromes in hypertension and/or periodontitis

mSystems
The microbiota plays an important role in both hypertension (HTN) and periodontitis (PD), and PD exacerbates the development of HTN by oral and gut microbiota.
Hui-Lin Ye, Meng-Fan Zhi, Bo-Yan Chen, Wen-Zhen Lin, Yu-Lin Li, Shi-Jia Huang, Lu-Jun Zhou, Shuo Xu, Jun Zhang, Wu-Chang Zhang, Qiang Feng, Sheng-Zhong Duan   +11 more
doaj   +1 more source

High-Level Acquisition of Maternal Oral Bacteria in Formula-Fed Infant Oral Microbiota

mBio, 2022
The influx of maternal oral microbes is considered to play an important role in the acquisition and development of infant oral microbiota. In this study, we examined tongue swab samples from 448 mother-infant pairs at 4-month checkups.
Shinya Kageyama, Michiko Furuta, Toru Takeshita, Jiale Ma, Mikari Asakawa, Yoshihisa Yamashita   +5 more
doaj   +1 more source

NCOR1 deficiency in mouse smooth muscle attenuates hypertension and vascular remodeling

Communications Biology
Smooth muscle nuclear receptor corepressor 1 (NCOR1) is implicated in phenotype modulation and aortic aneurysms, but its role in blood pressure regulation remains unclear.
Lin-Juan Du, Xiao-Qian Meng, Shuo Xu, Yan Liu, Lu-Jun Zhou, Wu-Chang Zhang, Sheng-Zhong Duan   +6 more
doaj   +1 more source

Intestinal microbiota in human health and disease: the impact of probiotics [PDF]

, 2011
The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the
Gerritsen, J., Vos, W.M., de, Ger T. Rijkers, Smidt, H., Jacoline Gerritsen, Rijkers, G.T., Willem M. de Vos, Hauke Smidt   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Differences in the microbiota of oral rinse, lesion, and normal site samples from patients with mucosal abnormalities on the tongue

Scientific Reports, 2022
The oral microbiota associated with mucosal diseases, including oral squamous cell carcinoma and oral potentially malignant disorders, have been extensively analyzed at the phylum and genus levels.
Yawaka Shitozawa, Kaoru Haro, Midori Ogawa, Akihiko Miyawaki, Mitsumasa Saito, Kazumasa Fukuda   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source