Results 71 to 80 of about 251,345 (303)

The colon as a target for vaccination: quantification of lymphoid tissue in mouse colon prior to vaccination [PDF]

, 2006
Currently, most vaccines are given by injection. However, due to the inherent problems associated with injections, other routes of drug delivery are being researched, among them, the oral route.
Basit, AW, McConnell, E, Murdan, S
core  

Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model [PDF]

, 2016
Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interrogated the effect ...
A Blikslager, A Sheoran, AC White, AF Allam, AG Buret, AJ Benitez, AM Marchiando, Ana M. Lara, B Pantenburg, BA Leav, BD Kirkpatrick, BP Coutinho, BS Sheridan, C Maillot, C Wang, Carrie A. Cowardin, Cirle A. Warren, CR Weber, D Mondal, David T. Bolick, DG Agnew, DI Campbell, DT Bolick, DT Bolick, EA Maier, Edna I. Zaenker, EM Brown, F Heller, Francisco Jose Noronha, G Gorfu, G Widmer, GA Preidis, Glynis L. Kolling, Gregory A. Buck, HC Wang, HN Ehigiator, IC Castro, J Liu, James K. Roche, JB Parr, JE Galen, Jerrold R. Turner, JK Roche, JK Tumwine, John H. Moore, Joseph M. Vinetz, JR Mead, JR Turner, JW Priest, JY Chai, K Mølbak, KL Kotloff, KM D'Auria, L Lantier, L Lantier, LA Bartelt, LA Bartelt, LB Costa, LB Costa, Luther A. Bartelt, M Abe, M Barrier, M Deng, M Eguchi, M Jalovecká, M Kváč, M Taniuchi, MA Laxer, MA McArthur, MG Netea, MH Van Regenmortel, MJH Rytter, NR Klatt, OG Azevedo, P Medeiros, PA Manque, PA Manque, PC Okhuysen, PS Korpe, PS Korpe, R Haque, R Wahid, RD Newman, RE Black, Richard L. Guerrant, RP Lazarus, S Bhuiyan, S Lacroix-Lamandé, S Lacroix-Lamandé, S Sagodira, SC Nalle, SM Guk, SM Planchon, SP O'Hara, SP Spencer, SS Ajjampur, T Gebhardt, T Hoang, T Kinugasa, VA Cama, W Checkley, W Checkley, W Checkley, W Chen, YG Zhang, YH Su   +105 more
core   +5 more sources

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Vaccines against toxoplasma gondii : challenges and opportunities [PDF]

, 2009
Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects.
Aliberti J, Angus CW, Aosai F, Aosai F, Awan KJ, Beghetto E, Bommireddy R, Bonenfant C, Boyle JP, Brinkmann V, Buxton D, Bülow R, Caetano BC, Conacher M, Cong H, Cong H, Constant SL, Couper KN, Craig W Roberts, Cui YL, Cuppari AF, Curtsinger JM, Curtsinger JM, Cutchins EC, Darcy F, Dautu G, Debard N, Debierre-Grockiego F, DeGregorio E, Denkers EY, Desolme B, Duquesne V, Echeverria PC, Elisabeth Förster-Waldl, Erik Jongert, Escajadillo A, Eskild Petersen, Fachado A, Fachado A, Flori P, Fox B, Frenkel JK, Garcia JL, Garcia JL, Gatkowska J, Gazzinelli R, Gazzinelli RT, Golkar M, Hakim FT, Igarashi M, Innes EA, Ishii K, Ishii KJ, Ismael AB, Ismael AB, Johnson LL, Jongert E, Jongert E, Jongert E, Kasper LH, Khan IA, Kijlstra A, Kodjikian L, Krahenbuhl JL, Kringel H, Letscher-Bru V, Letscher-Bru V, Leyva R, Lindsay DS, Liu Q, Lourenco EV, Lourenço EV, Martin V, McLeod R, Mishima M, Mishima M, Mohamed RM, Mévélec MN, Mévélec MN, Nicola Gargano, Nielsen HV, Nielsen HV, Petersen E, Petrovsky N, Pettersen EK, Pfefferkorn ER, Qu D, Reikvam A, Roque-Resendiz JL, Sabin AB, Sayles PC, Schaap D, Scorza T, Siachoque H, Sibley LD, Silveira C, Stanley AC, Stockinger B, Supply P, Taneja V, Vandepapelierea P, Velge-Roussel F, Velge-Roussel F, Vercammen M, Vogel N, Vyas JM, Waldeland H, Wang H, Wilkins MF, Williams MA, Xue M, Xue M, Yang CD, Yarovinsky F, Zenner L, Zhang G, Zhang J, Zimmermann S   +117 more
core   +3 more sources

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Vaccine coverage and determinants of incomplete vaccination in children aged 12-23 months in dschang, west region, cameroon: a cross-sectional survey during a polio outbreak [PDF]

, 2015
Inadequate immunization coverage with increased risk of vaccine preventable diseases outbreaksremains a problem in Africa. Moreover, different factors contribute to incomplete vaccination status. This study wasperformed in Dschang (West Region, Cameroon),
Biguioh, Rodrigue Mabvouna, Bouting Mayaka, Georges, Miglietta, Alessandro, Pezzotti, Patrizio, Rezza, Giovanni, Russo, Gianluca, Sobze, Martin Sanou, Stefanelli, Paola, Vullo, Vincenzo   +8 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]

, 2004
BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC, Fine, PEM, Floyd, S, Glynn, JR, Malema, SS, Mwaungulu, FD, Mwinuka, VK, Ngwira, BMM, Warndorff, DK   +8 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants

Human Vaccines & Immunotherapeutics, 2017
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe between 1997–2001, before ...
James A. Church, Sandra Rukobo, Margaret Govha, Marya P. Carmolli, Sean A. Diehl, Bernard Chasekwa, Robert Ntozini, Kuda Mutasa, Jean H. Humphrey, Beth D. Kirkpatrick, Andrew J. Prendergast   +10 more
doaj   +1 more source