Results 71 to 80 of about 127,439 (309)

The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model

, 2015
Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis in the developed world. Two potent cytotoxins, toxin A (TcdA) and toxin B (TcdB) are the virulence factors of this disease and can be a good vaccine ...
Moreira, Maira Aparecida S., Chang, Yung-Fu, Guo, Shanguang, He, Hongxuan, Yan, Weiwei, Xiang, Hua, Wu, Katherine J., Lin, Nengfeng, McDonough, Sean P., Yang, Maosheng   +9 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants

Human Vaccines & Immunotherapeutics, 2017
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe between 1997–2001, before ...
James A. Church, Sandra Rukobo, Margaret Govha, Marya P. Carmolli, Sean A. Diehl, Bernard Chasekwa, Robert Ntozini, Kuda Mutasa, Jean H. Humphrey, Beth D. Kirkpatrick, Andrew J. Prendergast   +10 more
doaj   +1 more source

Stockpiling oral cholera vaccine

Bulletin of the World Health Organization, 2012
Cholera is re-emerging as a threat on the global public health stage. The number of reported cases worldwide is back at the peak level observed two decades ago,1 new Vibrio cholerae strains have appeared and antimicrobial resistance has increased. Weak surveillance systems and the possibility of travel and trade sanctions contribute to widespread ...
Stephen Martin, Alejandro Costa, William Perea   +2 more
openaire   +3 more sources

The use of a computerized database to monitor vaccine safety in Viet Nam. [PDF]

, 2005
Health information systems to monitor vaccine safety are used in industrialized countries to detect adverse medical events related to vaccinations or to prove the safety of vaccines. There are no such information systems in the developing world, but they
Ali, Mohammad, Canh, Gia Do, Park, Jin-Kyung, Minh, Tan Truong, Clemens, John D, Thiem, Dinh Vu, von Seidlein, Lorenz, Tho, Huu Le, Vaccine Safety Datalink Group, Trach, Duc Dang   +9 more
core  

Use of an oral diphtheria vaccine in human

, 2006
Starch microparticles have been shown to be effective as a particulate adjuvant carrier in oral vaccination. In mice, formulations with bacterial antigens have elicited both systemic and mucosal immune responses providing protection upon challenge with ...
Stålenheim, Gunnemar,, Sjöholm, Ingvar,, Rydell, Niclas,, Stertman, Linda,   +3 more
core   +1 more source

Oral vaccination of wildlife against rabies: Differences among host species in vaccine uptake efficiency [PDF]

, 2017
Oral vaccination using attenuated and recombinant rabies vaccines has been proven a powerful tool to combat rabies in wildlife. However, clear differences have been observed in vaccine titers needed to induce a protective immune response against rabies ...
Conrad M. Freuling, Hundt, B., Ad Vos, Kaiser, C., Nolden, Tobias, Andreas Neubert, Verena te Kamp, Reiner Ulrich, te Kamp , Verena, Müller, Thomas, Nemitz, Sabine, Christiane Kaiser, Stefan Finke, Teifke, Jens Peter, Freuling, Conrad Martin, Jens P. Teifke, Neubert, A., Thomas Müller, Sabine Nemitz, Ulrich, Reiner Georg, Boris Hundt, Tobias Nolden, Vos, Ad, Finke, Stefan   +23 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Antitumor effect of oral cancer vaccine with Bifidobacterium delivering WT1 protein to gut immune system is superior to WT1 peptide vaccine

Human Vaccines & Immunotherapeutics, 2018
Despite the revolutionary progress of immune checkpoint inhibitors (CPIs) for cancer immunotherapy, CPIs are effective only in a subset of patients. Combining CPIs and cancer vaccines to achieve better clinical outcomes is a reasonable approach since CPI
Toshiro Shirakawa, Koichi Kitagawa
doaj   +1 more source

Changes in serogroup and genotype prevalence among carried meningococci in the United Kingdom during vaccine implementation [PDF]

, 2011
Natural fluctuations in carried meningococcal genotypes and phenotypes a can be affected by the use of conjugate vaccines, and not all of these changes are anticipatable in advance of vaccine ...
McCarthy, Noel D., Maclennan, Jenny, Evans, Meirion R, Rachel Urwin, Cameron, J. Claire, Neal, Keith R, Ibarz-Pavón, AB, Nicholas J. Andrews, Stuart C. Clarke, Cann, Kathryn, Maiden, MC, Noel D. McCarthy, Cameron, JC, Evans, MR, Maiden, Martin, James M. Stuart, Harrison, S, Ala'aldeen, Dlawer, Cunningham, Richard, Martin C. J. Maiden, Jolley, Keith A, Derrick W. Crook, Dlawer Ala'Aldeen, Walker, AM, Baxter, David, Gray, Stephen J., Urwin, R, Crook, Derrick W., Keith R. Neal, Clarke, SC, Clarke, Stuart C, Maiden, Martin C. J., Jolley, Keith A., Stuart, James M., Maiden, Martin CJ, Maclennan, J, Keith A. Jolley, Kaczmarski, E, Walker, A. Mark, J. Simon Kroll, Richard Cunningham, Andrews, NJ, J. Claire Cameron, Crook, DW, Evans, Meirion Rhys, Harrison, Sarah, Andrews, Nicholas J, Ala'aldeen, D, Edward Kaczmarski, Baxter, D, McCarthy, Noel D, Cann, K, Crook, Derrick W, Kathryn Cann, Ibarz-Pavón, Ana Belén, Clarke, Stuart C., Evans, Meirion R., A. Mark Walker, Cunningham, R, Kroll, J. Simon, Kroll, J Simon, Neal, KR, Cameron, J Claire, Maiden, MCJ, Andrews, Nicholas J., Neal, Keith R., McCarthy, ND, Stephen J. Gray, Jenny MacLennan, Meirion R. Evans, Crook, Derrick, Urwin, Rachel, Stuart, James M, Stuart, JM, Sarah Harrison, Gray, SJ, Gray, Stephen J, Ana Belén Ibarz-Pavón, Walker, A Mark, Kaczmarski, Edward, David Baxter, Andrews, Nicholas J., Kroll, JS, Jolley, KA   +83 more
core   +1 more source