Results 81 to 90 of about 127,439 (309)

Induction of mucosal and systemic immune responses against the common O78 antigen of an oral inactivated ETEC vaccine in Bangladeshi children and infants

, 2022
We tested an oral enterotoxigenic Escherichia coli (ETEC) vaccine, ETVAX, consisting of inactivated E. coli overexpressing the most prevalent ETEC colonization factors (CFs) and a toxoid (LCTBA), in Bangladeshi children for capacity to induce mucosal and
Akhtar, M., Lundgren, Anna,, Kaim, Joanna,, Svennerholm, Ann-Mari,, Qadri, F., Bhuiyan, T. R., Maier, N., Bourgeois, A. L., Walker, R. I.   +8 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Antigen-displaying probiotic Bacillus subtilis spores induce subtle, strain-dependent immunomodulation in fish

Frontiers in Marine Science
Despite the availability of commercial vaccines against several pathogens, infectious diseases continue to cause substantial economic losses in aquaculture.
Gabriela Gonçalves, Gabriela Gonçalves, Rafaela A. Santos, Rafaela A. Santos, Isabel M. Cerezo, Tomás Gabriel, José Dias, Rui Magalhães, Rui Magalhães, Pedro Pousão-Ferreira, Pedro Pousão-Ferreira, Paula Enes, Paula Enes, Carolina Tafalla, Aires Oliva-Teles, Aires Oliva-Teles, Ana Couto, Ana Couto, Patricia Díaz-Rosales, Cláudia R. Serra, Cláudia R. Serra   +20 more
doaj   +1 more source

Do microRNAs play a role in the activity of plant-based vaccines?

Expert Review of Vaccines, 2017
Introduction: An important trend in vaccinology is the development of oral vaccines based on genetically modified plants. Areas covered: Several studies have suggested that dietary microRNAs from plants and other organisms are bioavailable upon oral ...
Sergio Rosales-Mendoza, Jorge A. Salazar-González   +1 more
doaj   +1 more source

Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein

, 2013
We have developed a new oral vaccine against enterotoxigenic Escherichia coli (ETEC) diarrhea containing killed recombinant E. coli bacteria expressing increased levels of ETEC colonization factors (CFs) and a recombinant protein (LCTBA), i.e.
Gustafsson, B, Bourgeois, L, Holmgren, Jan,, Lundgren, Anna,, Tobias, Joshua,, Jertborn, Marianne,, Walker, R, Svennerholm, Ann-Mari,, Carlin, N, Leach, Susannah,   +9 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin.

, 2009
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT ...
Kromann Ingrid, Woodrow, M, Novicki Deborah, Huo, Z, Del Giudice Giuseppe, Novicki, D, Rappuoli Rino, Thierry-Carstensen, B, Susan Barnett, Galiza, E, David J M Lewis, Rafaela Giemza, Andersen, P, Peter Andersen, Lewis David J. M., Barnett Susan, Maria Woodrow, Kromann, I, Giuseppe Del Giudice, Thierry-Carstensen Birgit, Giemza Rafaela, Ingrid Kromann, Andersen Peter, Lewis, DJ, Galiza Eva, Giemza, R, Huo Zhiming, Woodrow Maria, Deborah Novicki, Eva Galiza, Birgit Thierry-Carstensen, Rino Rappuoli, Del Giudice, G, Rappuoli, R, Barnett, S, Zhiming Huo   +35 more
core   +1 more source

Stakeholders' opinions and questions regarding the anticipated malaria vaccine in Tanzania [PDF]

, 2016
Within the context of combined interventions, malaria vaccine may provide additional value in malaria prevention. Stakeholders' perspectives are thus critical for informed recommendation of the vaccine in Tanzania.
Abdulla, S, Exavery, A, Ali, A, Abdulla, Salim, Elisa Sicuri, Romore, Idda, Sicuri, Elisa, Salim Abdulla, Kafuruki, Shubi, Shubi Kafuruki, Kimweri, Angela, Ali Ali, Angela Kimweri, Marcel Tanner, Kimweri, A, Mtenga, S, Romore, I, Tanner, Marcel, Sicuri, E, Idda Romore, Exavery, Amon, John Lusingu, Amon Exavery, Tanner, M, Mtenga, Sally, Sally Mtenga, Ali, Ali, Lusingu, J, Kafuruki, S, Lusingu, John   +29 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source