Results 41 to 50 of about 868,890 (267)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Pontos críticos de impacto em linhas de beneficiamento utilizadas para citros no Estado de São Paulo Evaluation of critical points of impact on citrus sorting lines in the State of São Paulo

Revista Brasileira de Fruticultura, 2006
A produção citrícola brasileira é uma das mais importantes para a fruticultura do País, comercializando principalmente para o mercado externo. O impacto mecânico é um fator importante a ser minimizado, visando a reduzir as perdas pós-colheita, diminuindo
Marcos David Ferreira, Michele Carvalho da Silva, Gustavo Garcia de Toledo Camargo, Lilian Amorim, Ivan Herman Fischer   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Non-Destructive Classification of Sweetness and Firmness in Oranges Using ANFIS and a Novel CCI–GLCM Image Descriptor

Applied Sciences
This study introduces a non-destructive computer vision method for estimating postharvest quality parameters of oranges, including maturity index, soluble solid content (expressed in degrees Brix), and firmness.
David Granados-Lieberman, Alejandro Israel Barranco-Gutiérrez, Adolfo R. Lopez, Horacio Rostro-Gonzalez, Miroslava Cano-Lara, Carlos Gustavo Manriquez-Padilla, Marcos J. Villaseñor-Aguilar   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Índice de qualidade em um latossolo amarelo coeso cultivado com citros Quality index in a cohesive yellow latosol cultivated with citrus

Revista Brasileira de Fruticultura, 2009
O Brasil é o maior produtor mundial de citros e exportador de suco concentrado de laranja. Na região Nordeste, a citricultura tem grande importância social, onde é cultivada predominantemente por produtores com áreas menores do que 10 hectares, em solos ...
José Fernandes de Melo Filho, Lícia Lemos de Carvalho, Dreid de Cerqueira Silveira, José Augusto Amorim Silva do Sacramento, Edvana Cássia Pinto Silveira   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Orange as an Orange

Jama'a: an Interdisciplinary Journal of Middle East Studies
يقترح هذا المقال محو اًرً للتطوّّر في شعريّّة النثر العربيّّ بعد أزمة 1967 ، ويضعه في مقارنة مع التحوّّلات الجماليّّة التي شهدتها الرواية خلال تلك الفترة. ففي حين اتّّجهت الرواية نحو الانفصال عن الواقعيّّة، اتّّجه العديد من شعراء النثر البارزين في اتّلاّجاه المعاكس، نحو الواقعيّّة الغنائيّّة وشعريّّة التفاصيل اليوميّّة.
openaire   +1 more source

Kebaikan Orang-Orang Kafir

Al-Kauniyah, 2022
Penelitian ini dilatar belakangi oleh perdebatan klise setiap tahunnya antara umat muslim dan nasrani, yaitu hari raya Natal. Perdebatan tentang mengucapkan selamat Natal yang terus-menerus mengalir menjadikan nya semakin merembet menuju celah-celah permasalahan lain, hingga pada puncaknya, bermuara pada surga dan neraka. Narasi “yang penting baik sama
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source