Results 61 to 70 of about 2,441,053 (311)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

AFLP Fingerprinting Analysis of Citrus Cultivars and Wild Accessions from Oman Suggests the Presence of Six Distinct Cultivars

Agriculture, 2018
A study was conducted to evaluate genetic relatedness of 27 citrus cultivars and 6 wild citrus accessions using AFLP fingerprinting. The 27 citrus cultivars belonged to Citrus sinensis, C. aurantifolia, C. aurantium, C. paradise, C. reticulata, C. limon,
Al-Nadabi Hamed, Khan Mumtaz, Al-Yahyai Rashid Abdullah, Al-Sadi Abdullah Mohammed   +3 more
doaj   +1 more source

Kebaikan Orang-Orang Kafir

Al-Kauniyah, 2022
Penelitian ini dilatar belakangi oleh perdebatan klise setiap tahunnya antara umat muslim dan nasrani, yaitu hari raya Natal. Perdebatan tentang mengucapkan selamat Natal yang terus-menerus mengalir menjadikan nya semakin merembet menuju celah-celah permasalahan lain, hingga pada puncaknya, bermuara pada surga dan neraka. Narasi “yang penting baik sama
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Olivine or Impact Melt: Nature of the "Orange" Material on Vesta from Dawn

, 2013
NASA's Dawn mission observed a great variety of colored terrains on asteroid (4) Vesta during its survey with the Framing Camera (FC). Here we present a detailed study of the orange material on Vesta, which was first observed in color ratio images ...
Ammanito, E., Becker, K., Cloutis, E., De Sanctis, M., Denevi, B., Gaffey, M., Garry, W., Gaskell, R., Kneisl, T., Le Corre, L., Li, J., Mittlefehldt, D., Nathues, A., O'Brien, D., Palmer, E., Peplowski, P., Prettyman, T., Raymond, C., Reddy, V., Russell, C., Schmedemann, N., Sierks, H., Yamashita, N.   +22 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Orange as an Orange

Jama'a: an Interdisciplinary Journal of Middle East Studies
يقترح هذا المقال محو اًرً للتطوّّر في شعريّّة النثر العربيّّ بعد أزمة 1967 ، ويضعه في مقارنة مع التحوّّلات الجماليّّة التي شهدتها الرواية خلال تلك الفترة. ففي حين اتّّجهت الرواية نحو الانفصال عن الواقعيّّة، اتّّجه العديد من شعراء النثر البارزين في اتّلاّجاه المعاكس، نحو الواقعيّّة الغنائيّّة وشعريّّة التفاصيل اليوميّّة.
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Effects of Various Steam Explosions on the Efficiency, Yield, and Loss in a Hydraulic Press Extractor of Fruit Juice

Jurnal Keteknikan Pertanian Tropis dan Biosistem
High post-harvest losses occur as a result of the fruits rapid decline in quality after harvest. Using a steam exploded simple juicer is one approach to make up for this loss.
Oluwafemi Babatunde Oduntan, Bankole, Adeleke Isaac Bamgboye, Abosede Oluwakemi Oduntan   +3 more
doaj   +1 more source