Results 71 to 80 of about 2,441,053 (311)

Estimating the R-curve from residual strength data [PDF]

open access: yes
A method is presented for estimating the crack-extension resistance curve (R-curve) from residual-strength (maximum load against original crack length) data for precracked fracture specimens.
Orange, T. W.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Observations of an Energetically Isolated Quiet Sun Transient: Evidence of Quasi-Steady Coronal Heating [PDF]

open access: yes, 2015
Increasing evidence for coronal heating contributions from cooler solar atmospheric layers, notably quiet Sun (QS) conditions, challenges standard solar atmospheric descriptions of bright transition region (TR) emission. As such, questions to the role of
Chesny, David L.   +2 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Pre-HOST high temperature crack propagation [PDF]

open access: yes
The highlights of NASA contract CR-167896, Fracture Mechanics Criteria for Turbine Engine Hot Section Components, are presented. The five technical tasks of the program are reviewed.
Orange, T. W.
core   +1 more source

SSR-Based genetic variability assessment of Tunisian local citrus rootstocks : [P22] [PDF]

open access: yes, 2008
In the framework of the 6th PCRD European Project 'CIBEWU', the genetic diversity of Tunisian Citrus rootstocks germplasm was assessed using microsatellite markers (SSR).
Belfalah, Zina   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A review of surface-crack fracture testing [PDF]

open access: yes
A brief historical review of surface-crack testing and analysis is given together with some examples of service failures due to surface cracks. The factors which complicate the analysis and interpretation of surface-crack fracture data are discussed ...
Orange, T. W.
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Effects of applying SC27 microbial soil fertility intensifier on orange

open access: yes浙江大学学报. 农业与生命科学版, 2001
The effects of SC27 microbial soil fertility intensifier on yield and quality of orange were studied. The results showed that growth of orange tree promoted and yield increased in a ratio of 7.2%-23.4% by SC27.
YU Dan-hong   +2 more
doaj   +1 more source

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