Results 71 to 80 of about 1,159,608 (316)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Orange County Reporter, February 21, 1884 [PDF]
, 1884 Orange County Reporter newspaper from February 21, 1884 to December 25, 1884.https://stars.library.ucf.edu/cfm-orangecountyreporter/1000/thumbnail ...
Orange County Reporter
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Gateway to Texas: The History of Orange and Orange County
, 1988 A book about the history of Orange and Orange County.
Williams, Howard C.
core
Orange County Reporter, November 20, 1884 [PDF]
, 1884 Orange County Reporter newspaper from February 21, 1884 to December 25, 1884.https://stars.library.ucf.edu/cfm-orangecountyreporter/1045/thumbnail ...
Orange County Reporter
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Orange County Reporter, April 24, 1884 [PDF]
, 1884 Orange County Reporter newspaper from February 21, 1884 to December 25, 1884.https://stars.library.ucf.edu/cfm-orangecountyreporter/1010/thumbnail ...
Orange County Reporter
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Orange County Reporter, July 17, 1884 [PDF]
, 1884 Orange County Reporter newspaper from February 21, 1884 to December 25, 1884.https://stars.library.ucf.edu/cfm-orangecountyreporter/1023/thumbnail ...
Orange County Reporter
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source