Results 41 to 50 of about 31,558 (310)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Multiresidual gas chromatography-tandem mass spectrometry method for determination of plant protection product residues in fruit [PDF]

Journal of Central European Agriculture
A multiresidual method for the determination of 29 active substances was developed and validated. Acetone, petroleum ether and dichloromethane were used for extraction, and a gas chromatograph coupled with a tandem mass spectrometer was used for ...
Helena BAŠA ČESNIK
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Growth inhibition of Penicillium digitatum by antagonistic microorganisms isolated from various parts of orange tree [PDF]

Maejo International Journal of Science and Technology, 2007
Penicillium digitatum (Pers.:Fr) Sacc. is the major cause of green mold disease in orange trees grown for orange production industry in Thailand. In this study, antagonistic microorganisms were isolated from various parts of healthy orange trees. A total
Wasu Pathom-aree
doaj  

New late-season navel orange varieties evaluated for quality characteristics

California Agriculture, 2007
New early- and late-maturing navel orange varieties have expanded the navel orange season for California's domestic and export fresh-fruit market.
Tracy Kahn, Ottillia Bier, Robert Beaver
doaj   +1 more source

Mensuração da interdisciplinaridade nos cursos de graduação em Administração [PDF]

, 2019
O artigo propõe um modelo de mensuração da interdisciplinaridade nos cursos de graduação em Administração. A survey eletrônica foi realizada nos cursos avaliados pelo Enade 2009 e os dados tratados pela Análise Fatorial e de Conglomerados.
Cezarino, Luciana Oranges, Corrêa, Hamilton Luiz, Hamilton Luiz Corrêa, Luciana Oranges Cezarino, Hamilton Luiz Corrêa, Luciana Oranges Cezarino   +5 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

ESTUDO DA ORIENTAÇÃO DE LARANJAS IMERSAS EM ÁGUA

Revista Brasileira de Engenharia Agrícola e Ambiental
RESUMO À medida que o custo de métodos tradicionais de transporte mecânico ou manual aumenta, existe a possibilidade de que o transporte hidráulico de laranjas em canais, como já é empregado em algumas indústrias nacionais, se torne economicamente ...
Maria Elita Duarte Braga, Carlos Alberto Gasparetto   +1 more
doaj   +1 more source