Results 91 to 100 of about 86,122 (316)

The fundamental group of the orbit space

Annals of the West University of Timisoara: Mathematics and Computer Science, 2015
Let G be a subgroup of the group Homeo(X) of homeomorphisms of a topological space X. Let G¯$\bar G$ be the closure of G in Homeo(X). The class of an orbit O of G is the union of all orbits having the same closure as O. We denote by X/G˜$X/\widetildeG$
Hattab Hawete
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Multidisciplinary design of a micro-USV for re-entry operations

, 2010
Unmanned Space Vehicles (USV) are seen as a test-bed for enabling technologies and as a carrier to deliver and return experiments to and from low-Earth orbit.
Liqiang, Hou, Vasile, Massimiliano, Edmondo Minisci, Hou Liqiang, Minisci, Edmondo, Massimiliano Vasile   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DLR’s Advanced Telerobotic Concepts and Experiments for On-Orbit Servicing

, 2007
Summary. Space robotics will become a key technology for the exploration of outer space and the operation and maintenance of space stations, satellites and other plat-forms, saving costs and relieving man from dangerous tasks.
Hirzinger, Gerd, Landzettel, Klaus, Reintsema, Detlef, Klaus L, Gerd Hirzinger, Detlef Reintsema   +5 more
core  

Ascent trajectory optimisation for a single-stage-to-orbit vehicle with hybrid propulsion [PDF]

, 2012
This paper addresses the design of ascent trajectories for a hybrid-engine, high performance, unmanned, single-stage-to-orbit vehicle for payload deployment into low Earth orbit. A hybrid optimisation technique that couples a population-based, stochastic
Taylor, Ian, Edmondo Minisci, Ian Taylor, Fabrizio Pescetelli, Christie Maddock, Minisci, Edmondo, Maddock, Christie, Richard Brown, Pescetelli, Fabrizio, Brown, Richard   +9 more
core   +1 more source

Function spaces for orbit-finite sets

CoRR
Orbit-finite sets are a generalisation of finite sets, and as such support many operations allowed for finite sets, such as pairing, quotienting, or taking subsets. However, they do not support function spaces, i.e. if X and Y are orbit-finite sets, then the space of finitely supported functions from X to Y is not orbit-finite. In this paper we propose
Bojańczyk, Mikołaj, Nguyễn, Lê Thành Dũng, Stefański, Rafał   +2 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prediction of the aerodynamic performance of re-usable single stage to orbit vehicles

, 2011
Re-usable single stage to orbit launch vehicles promise to reduce the cost of access to space, but their success will be particularly reliant on accurate modelling of their aero-thermodynamic characteristics.
Maddock, Christie, Scanlon, Thomas, Ahmad, Abdul Ossman, Brown, Richard   +3 more
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source