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The orbitofrontal cortex: reward, emotion and depression [PDF]
Brain Communications, 2020 AbstractThe orbitofrontal cortex in primates including humans is the key brain area in emotion, and in the representation of reward value and in non-reward, that is not obtaining an expected reward. Cortical processing before the orbitofrontal cortex is about the identity of stimuli, i.e. ‘what’ is present, and not about reward value. There is evidence
Jianfeng Feng +2 more
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Current Biology, 2018 The orbitofrontal cortex is a large and heterogeneous cortical area on the ventral surface of the frontal lobe and is intimately involved in emotion and executive function. In this Primer, Peter Rudebeck and Erin Rich summarize our understanding of the mechanisms through which orbitofrontal cortex adaptively shapes decision making and affective ...
Peter H, Rudebeck, Erin L, Rich
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Abnormal Spontaneous Neural Activity in Obsessive-Compulsive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study. [PDF]
PLoS ONE, 2013 Neuroimaging studies of obsessive-compulsive disorder have found abnormalities in orbitofronto-striato-thalamic circuitry, including the orbitofrontal cortex, anterior cingulate cortex, caudate, and thalamus, but few studies have explored abnormal ...
Li Ping +8 more
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The State of the Orbitofrontal Cortex [PDF]
Neuron, 2015 State representation is fundamental to behavior. However, identifying the true state of the world is challenging when explicit cues are ambiguous. Here, Bradfield and colleagues show that the medial OFC is critical for using associative information to discriminate ambiguous states.
Sharpe, Melissa J. +3 more
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Frontiers in Neuroscience, 2023 IntroductionThe present study aims to explore the extent to which auditory processing is reflected in the prefrontal cortex.MethodsUsing magnetoencephalography (MEG), we investigated the chronology of primary and secondary auditory responses and ...
Steffen Bücher +8 more
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Risk-taking in humans and the medial orbitofrontal cortex reward system
NeuroImage, 2022 Risk-taking differs between humans, and is associated with the personality measures of impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk-taking, resting state functional connectivity, and related behavioral ...
Edmund T. Rolls +3 more
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The magical orbitofrontal cortex. [PDF]
Behavioral Neuroscience, 2021 This special issue, commissioned after the 4th Quadrennial Meeting on Orbitofrontal Cortex Function held in Paris in November of 2019 (https://ofc2019.sciencesconf.org/), is intended to provide a snapshot of this ongoing transformation; we hope that the ideas presented herein will provide a foundation for the next stage in the evolution of our ...
Schoenbaum, Geoffrey +4 more
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Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis
NeuroImage: Clinical, 2020 Neural models of obesity vary in their focus upon prefrontal and striatal differences. Animal and human studies suggest that differential functioning of the orbitofrontal cortex is associated with obesity.
Eunice Y. Chen +3 more
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The Orbitofrontal Cortex in Temporal Cognition [PDF]
Behavioral Neuroscience, 2020 Abstract One of the most important factors in decision making is estimating the value of available options. Subregions of the prefrontal cortex, including the orbitofrontal cortex (OFC), have been deemed essential for this process. Value computations require a complex integration across numerous dimensions, including, reward magnitude ...
Juan Luis Romero Sosa +2 more
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PLoS Biology, 2020 One of the most influential accounts of central orbitofrontal cortex-that it mediates behavioral flexibility-has been challenged by the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is unaffected when ...
Jérôme Sallet +16 more
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