Results 11 to 20 of about 87,713 (271)
The orbitofrontal cortex: reward, emotion and depression [PDF]
Brain Communications, 2020 AbstractThe orbitofrontal cortex in primates including humans is the key brain area in emotion, and in the representation of reward value and in non-reward, that is not obtaining an expected reward. Cortical processing before the orbitofrontal cortex is about the identity of stimuli, i.e. ‘what’ is present, and not about reward value. There is evidence
Edmund T Rolls, Wei Cheng, Jianfeng Feng
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The orbitofrontal cortex maps future navigational goals [PDF]
Nature, 2021 Abstract Accurate navigation to a desired goal requires consecutive estimates of spatial relationships between the current position and future destination throughout the journey. Although neurons in the hippocampal formation can represent the position of an animal as well as its nearby trajectories
Raunak Basu +6 more
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Spatial Representations in Rat Orbitofrontal Cortex [PDF]
The Journal of Neuroscience, 2021 The orbitofrontal cortex (OFC) and hippocampus share striking cognitive and functional similarities. As a result, both structures have been proposed to encode "cognitive maps" that provide useful scaffolds for planning complex behaviors. However, while this function has been exemplified by spatial coding in neurons of hippocampal regions-particularly ...
Andrew M. Wikenheiser +3 more
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The stressed orbitofrontal cortex.
Behavioral Neuroscience, 2021 Stressor exposure causes dendritic remodeling on excitatory neurons in multiple regions of the brain, including the orbitofrontal cortex (OFC). Additionally, stressor and exogenous stress hormone exposure impair cognitive functions that are dependent on the OFC.
Michelle K. Sequeira, Shannon L. Gourley
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Orbitofrontal Cortex and Memory Formation [PDF]
Neuron, 2002 Which one of the many regions of the anatomically heterogeneous prefrontal cortex is part of the critical core of the neural circuit for encoding? This positron emission tomography (PET) experiment measured changes in cerebral blood flow (CBF) in normal human participants during the presentation of abstract visual information in four conditions that ...
Frey, Stephen, Petrides, Michael
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PLoS Biology, 2020 One of the most influential accounts of central orbitofrontal cortex-that it mediates behavioral flexibility-has been challenged by the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is unaffected when ...
Jérôme Sallet +16 more
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Frontiers in Psychiatry, 2022 BackgroundSchizophrenia (SZ) is associated with the highest disability rate among serious mental disorders. Excited symptoms are the core symptoms of SZ, which appear in the early stage, followed by other stages of the disease subsequently.
Congxin Chen +7 more
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Testosterone reduces amygdala–orbitofrontal cortex coupling [PDF]
Psychoneuroendocrinology, 2010 Testosterone influences various aspects of affective behavior, which is mediated by different brain regions within the emotion circuitry. Previous neuroimaging studies have demonstrated that testosterone increases neural activity in the amygdala. To investigate whether this could be due to altered regulation of amygdala functioning which is thought to ...
Wingen, G.A. van +4 more
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Meta-reinforcement learning via orbitofrontal cortex
Nature Neuroscience, 2023 AbstractThe meta-reinforcement learning (meta-RL) framework, which involves RL over multiple timescales, has been successful in training deep RL models that generalize to new environments. It has been hypothesized that the prefrontal cortex may mediate meta-RL in the brain, but the evidence is scarce.
Ryoma Hattori +9 more
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Frontiers in Behavioral Neuroscience, 2022 Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom, for which the underlying pathology has not yet been fully understood.
Linda Becker +3 more
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