Results 61 to 70 of about 128,939 (270)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A Generic Deployment Framework for Grid Computing and Distributed Applications [PDF]

, 2006
Deployment of distributed applications on large systems, and especially on grid infrastructures, becomes a more and more complex task. Grid users spend a lot of time to prepare, install and configure middleware and application binaries on nodes, and ...
Flissi, Areski, Merle, Philippe
core   +4 more sources

Assessing the level of maturity of a territory's innovation ecosystem: methodological foundations and tools

π-Economy
Models for assessing the level of digital maturity are widely used as a tool for justifying decisions on the development of organizations. Similar models exist in the field of assessing the maturity of ecosystems.
Gileva Tatiana
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Semantic model-driven development of web service architectures. [PDF]

, 2008
Building service-based architectures has become a major area of interest since the advent of Web services. Modelling these architectures is a central activity. Model-driven development is a recent approach to developing software systems based on the idea
Pahl, Claus
core   +2 more sources

Orchestrating innovation networks: Alignment and orchestration profile approach

Journal of Business Research, 2022
Abstract This conceptual paper organizes and advances existing knowledge on the management practices of inter-organizational innovation networks by developing an orchestration profile approach. We utilize the principle of alignment to connect orchestration practices with the management requirements of different types of innovation networks.
Hurmelinna-Laukkanen, Pia, Möller, Kristian, Nätti, Satu   +3 more
openaire   +4 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rentable Internet of Things Infrastructure for Sensing as a Service (S2aaS) [PDF]

, 2018
Sensing as a Service (S2aaS) model [1] [2] is inspired by the traditional Everything as a service (XaaS) approaches [3]. It aims to better utilize the existing Internet of Things (IoT) infrastructure. S2aaS vision aims to create 'rentable infrastructure'
Perera, Charith
core   +2 more sources

Creating Tailored and Adaptive Network Services with the Open Orchestration C-RAN Framework

, 2018
Next generation wireless communications networks will leverage software-defined radio and networking technologies, combined with cloud and fog computing. A pool of resources can then be dynamically allocated to create personalized network services (NSs).
Floriach-Pigem, Marti, Gelonch-Bosch, Antoni, Marojevic, Vuk, Xercavins-Torregrosa, Guillem   +3 more
core   +1 more source