Results 41 to 50 of about 166,365,585 (292)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On Multivariate Bernstein Polynomials
Mathematics, 2020 In this paper, we first revisit and bring together as a sort of survey, properties of Bernstein polynomials of one variable. Secondly, we extend the results from one variable to several ones, namely—uniform convergence, uniform convergence of the ...
Mama Foupouagnigni +1 more
doaj +1 more source
The second order spectrum and optimal convergence [PDF]
Mathematics of Computation, 2013 The method of second order relative spectra has been shown to reliably approximate the discrete spectrum for a self-adjoint operator. We extend the method to normal operators and find optimal convergence rates for eigenvalues and eigenspaces. The convergence to eigenspaces is new, while the convergence rate for eigenvalues improves on the previous ...
openaire +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Complete convergence for arrays of minimal order statistics
International Journal of Mathematics and Mathematical Sciences, 2004 For arrays of independent Pareto random variables, this paper establishes complete convergence for weighted partial sums for the smaller order statistics within each row. This result improves on past strong laws.
André Adler
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Coming Multi-Order World [PDF]
, 2016 The article shows that the current international system is changing towards a completely new form of international system, conceptualized as a multi-order system. The suggestion for a multi-order world stands in contrast to three current narratives about
Flockhart, Trine
core +1 more source
Generalized convergence analysis of the fractional order systems
Open Physics, 2018 The aim of the present work is to generalize the contraction theory for the analysis of the convergence of fractional order systems for both continuous-time and discrete-time systems.
Ruzitalab Ahmad +2 more
doaj +1 more source