Results 51 to 60 of about 173,725,199 (293)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Generalized convergence analysis of the fractional order systems

Open Physics, 2018
The aim of the present work is to generalize the contraction theory for the analysis of the convergence of fractional order systems for both continuous-time and discrete-time systems.
Ruzitalab Ahmad, Farahi Mohammad Hadi, Erjaee Gholamhossien   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

I−LACUNARY STATISTICAL CONVERGENCE OF ORDER β OF DIFFERENCE SEQUENCES OF FRACTIONAL ORDER [PDF]

, 2021
In this paper, we introduce the concepts of ideal ∆α−lacunary statis- tical convergence of order β with the fractional order of α and ideal ∆α−lacunary strongly convergence of order β with the fractional order of α ( where 0 < β ≤ 1and α be a fractional ...
Şengül Kandemir, Hacer, Aral, Nazlım Deniz, Nazlım Deniz Aral, Hacer Şengül Kandemir   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

On the R-order of convergence of Newton's method under mild differentiability conditions [PDF]

, 2006
A new technique is used instead of the classical majorant principle to analyze the R-order of convergence of the Newton process when more general conditions than the Kantorovich ones are ...
Ezquerro, J.A., J.A. Ezquerro, M.A. Hernández, Ezquerro, J.A. [0000-0001-8120-167X], Hernández, M.A. [0000-0001-5478-2958], Hernández, M.A.   +5 more
core   +1 more source

Ball Comparison for Some Efficient Fourth Order Iterative Methods Under Weak Conditions

Mathematics, 2019
We provide a ball comparison between some 4-order methods to solve nonlinear equations involving Banach space valued operators. We only use hypotheses on the first derivative, as compared to the earlier works where they considered conditions reaching up ...
Ioannis K. Argyros, Ramandeep Behl
doaj   +1 more source

Highly efficient numerical scheme for solving fuzzy system of linear and non-linear equations with application in differential equations

Applied Mathematics in Science and Engineering, 2022
In this research, we suggested a numerical iterative scheme for investigating the numerical solution of fuzzy linear and nonlinear systems of equations, particularly where the linear or nonlinear system co-efficient is a crisp number and the right-hand ...
Mudassir Shams, Nasreen Kausar, Praveen Agarwal, Shaher Momani, Mohd Asif Shah   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Study of Convergence of Sixth-Order Contraharmonic-Mean Newton’s Method (CHN) with Applications and Dynamics

Foundations
We develop the local convergence of the six order Contraharmonic-mean Newton’s method (CHN) to solve Banach space valued equations. Our analysis approach is two fold: The first way uses Taylor’s series and derivatives of higher orders.
Manoj K. Singh, Ioannis K. Argyros, Samundra Regmi   +2 more
doaj   +1 more source