Results 91 to 100 of about 10,424,213 (314)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Recent advances and applications of human brain models

Frontiers in Neural Circuits
Recent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids.
Kaneyasu Nishimura, Hironobu Osaki, Kotaro Tezuka, Daisuke Nakashima, Shintaro Numata, Yoshito Masamizu   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy

Journal of Magnetic Resonance Open
Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes ...
Bowen Han, Jing He, Shaohua Huang
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Orders in quadratic fields, II

Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1993
This work continues part I with the same title [ibid., No. 3, 45-48 (1993; Zbl 0795.11056)] and also complements the work of the authors where they dealt with the real case [Reduced ideals, the divisor function, continued fractions and class numbers of real quadratic fields, to appear in Publ. Math.].
Mollin, R. A., Zhang, L.-C.
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Application of Ordered Porous Silica Materials in Drug Delivery: A Review

Molecules
Nanotechnology has significantly advanced various fields, including therapeutic delivery, through the use of nanomaterials as drug carriers. The biocompatibility of ordered porous silica materials makes them promising candidates for drug delivery systems,
Wenwen Liu, Junlin Wu, Zehao Jiang, Xinyu Zhang, Zhenxiang Wang, Fanjun Meng, Zidi Liu, Teng Zhang   +7 more
doaj   +1 more source

Non-Abelian gauged fracton matter field theory: Sigma models, superfluids, and vortices

Physical Review Research, 2020
By gauging a higher-moment polynomial degree global symmetry and a discrete charge conjugation (i.e., particle-hole) symmetry coupled to matter fields (two symmetries mutually noncommutative), we derive a class of higher-rank tensor non-Abelian gauge ...
Juven Wang, Shing-Tung Yau
doaj   +1 more source

Ordered fields satisfying Pólya’s theorem [PDF]

Proceedings of the American Mathematical Society, 2005
The purpose of this paper is to characterize ordered fields satisfying Pólya’s theorem on positive representations of polynomials. As a main result, it is proved that an ordered field ( F , ≤ ) (F,\le ) satisfies Pólya’s theorem if and only if ≤ \le is an archimedean ordering and
openaire   +2 more sources