Results 91 to 100 of about 384,616 (321)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Modified Riccati technique for half-linear differential equations with delay

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2014
We study the half-linear differential equation $$ (r(t)\Phi(x'(t)))'+c(t)\Phi(x(\tau(t)))=0,\quad \Phi(x):=|x|^{p-2}x,\ p>1. $$ We formulate new oscillation criteria for this equation by comparing it with a certain ordinary linear or half-linear ...
Simona Fišnarová, Robert Marik
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Complex-Valued Ordinary Differential Equation Modeling for Time Series Identification

open access: yesIEEE Access, 2019
Time series identification is one of the key approaches to dealing with time series data and discovering the change rules. Therefore, time series forecasting can be treated as one of the most challenging issues in this field.
Bin Yang, Wenzheng Bao
doaj   +1 more source

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