Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Existence and uniqueness of a local solution for x' = f(t,x) using inverse functions
Electronic Journal of Differential Equations, 2013 A condition on the function $f$ is given such that the scalar ordinary differential equation $x' = f(t,x)$ with initial condition $x(t_0) = x_0$ has a unique solution in a neighborhood of $t_0$. An example illustrates that this result can be used when
Jeffrey T. Hoag
doaj
Step-by-step comparison of ordinary differential equation and agent-based approaches to pharmacokinetic-pharmacodynamic models. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2022 Truong VT +5 more
europepmc +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Existence of periodic solutions for a semilinear ordinary differential equation
Electronic Journal of Differential Equations, 1998 Dancer [3] found a necessary and sufficient condition for the existence of periodic solutions to the equation $$ ddot x +g_1(dot x) + g_0(x) = f(t),.$$ His condition is based on a functional that depends on the solution to the above equation with $g_0=0$.
Petr Girg
doaj
Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models. [PDF]
PLoS Comput Biol, 2022 Fröhlich F, Sorger PK.
europepmc +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
A nonlinear sparse neural ordinary differential equation model for multiple functional processes. [PDF]
Can J Stat, 2022 Liu Y, Li L, Wang X.
europepmc +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
AMICI: high-performance sensitivity analysis for large ordinary differential equation models. [PDF]
Bioinformatics, 2021 Fröhlich F +7 more
europepmc +1 more source