Results 61 to 70 of about 138,809 (284)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Functional Determinants for Radially Separable Partial Differential Operators

Acta Polytechnica, 2007
Functional determinants of differential operators play a prominent role in many fields of theoretical and mathematical physics, ranging from condensed matter physics, to atomic, molecular and particle physics.
G. V. Dunne
doaj  

Solution of the inverse spectral problem for differential operators on a finite interval with complex weights [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
Non-self-adjoint second-order ordinary differential operators on a finite interval with complex weights are studied. Properties of spectral characteristics are established, and the inverse problem of recovering operators from their spectral ...
Yurko, Vjacheslav Anatol'evich
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quantum curves

, 2014
One says that a pair (P,Q) of ordinary differential operators specify a quantum curve if [P,Q]=const. If a pair of difference operators (K,L) obey the relation KL=const LK we say that they specify a discrete quantum curve. This terminology is prompted by
Schwarz, Albert
core   +1 more source

Dissipative Ordinary Differential Operators of Even Order [PDF]

Transactions of the American Mathematical Society, 1967
The aim of this paper is to study the Cauchy problem for the system (1.1). We shall make the following three assumptions: (1.2) B=B*, C=-C*, D=-D*,..., T=-T*; (1.3) Z-=Bx+A+A* 1 in L2(a, b; F) defined by 1 =a( (Fy, y) dx and a norm IYi= [KY, Y>i]112, L2(a, b; F) becomes a Hilbert space which we shall sometimes denote by H1.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Characterization of domains of symmetric and self-adjoint ordinary differential operators

Electronic Journal of Differential Equations, 2018
We characterize the two point boundary conditions which determine symmetric ordinary differential operators of any order, even or odd, with complex coefficients and arbitrary deficiency index, in a Hilbert space.The self-adjoint characterizations ...
Aiping Wang, Anton Zettl
doaj  

Fast Computation of Common Left Multiples of Linear Ordinary Differential Operators

, 2012
We study tight bounds and fast algorithms for LCLMs of several linear differential operators with polynomial coefficients. We analyze the arithmetic complexity of existing algorithms for LCLMs, as well as the size of their outputs.
Bostan, Alin, Chyzak, Frédéric, Li, Ziming, Salvy, Bruno   +3 more
core   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source