Results 131 to 140 of about 127,842,725 (298)

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

A novel vascularized urethra-on-a-chip model

Scientific Reports
The male urethra transports urine and semen. Any disease of the male urethra, hindering normal voiding or ejaculation, has a major impact on quality of life. Urethral stricture disease is common and molecular research into urethral strictures is hampered
Aina Casademont-Roca, Zhentao Xing, Murillo Bernardi, Maarten Rookmaker, Laetitia de Kort, Petra de Graaf   +5 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Microfluidic technologies: from fundamental principles to advanced fabrication and applications

AAPS Open
Conventional drug delivery systems, model study systems, drug analysis systems and drug interactions systems have been in use since ages. But these conventional methods struggle with significant limitations like lack of precise targeting, irregular ...
Rupam Deka, Shrutie Shivam, Debarupa Dutta Chakraborty, Prithviraj Chakraborty   +3 more
doaj   +1 more source

Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

Biosensors
Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient drug development frameworks, driving the emergence of organ-on-a-chip (OOC) based on ...
Sheng Yuan, Huipu Yuan, David C. Hay, Huan Hu, Chaochen Wang   +4 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Development of Organ-on-a-Chip System with Continuous Flow in Simulated Microgravity

Micromachines
Organ-on-a-chip (OOC) is an innovative microfluidic device mimicking the structure and functionality of real tissue. OOCs typically involve cell culture with microfluidics to emulate the biological forces of different organ tissues and disease states ...
Arnis Strods, Karīna Narbute, Valērija Movčana, Kévin Gillois, Roberts Rimša, Patrik Hollos, Fēlikss Rūmnieks, Arnita Spule, Gatis Mozoļevskis, Arturs Abols   +9 more
doaj   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

, 2018
Liver organoids derived from human pluripotent stem cells (PSCs) represent a new type of in vitro liver model for understanding organ development, disease mechanism and drug testing.
Qin, Jianhua, Wang, Yaqing, Wang, Hui, Guo, Yaqiong, Deng, Pengwei, Chen, Wenwen, Tao, Tingting   +6 more
core   +1 more source

A Versatile and Modular Microfluidic System for Dynamic Cell Culture and Cellular Interactions

Micromachines
A versatile and modular microfluidic system for cell co-culture has been developed. Microfluidic chips, each featuring dual compartments separated by a porous membrane, have been fabricated and assembled within the system to facilitate fluidic ...
Qasem Ramadan, Rana Hazaymeh, Mohammed Zourob   +2 more
doaj   +1 more source