Results 261 to 270 of about 91,588,802 (303)
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2020
Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
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Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
openaire +2 more sources
Scientific American, 2011
The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
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The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
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2021
Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
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Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
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Engineered Biomimetic Membranes for Organ-on-a-Chip
ACS Biomaterials Science & Engineering, 2022Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems.
Maedeh Rahimnejad +12 more
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Organs-on-a-chip for drug discovery
Current Opinion in Pharmacology, 2013The current drug discovery process is arduous and costly, and a majority of the drug candidates entering clinical trials fail to make it to the marketplace. The standard static well culture approaches, although useful, do not fully capture the intricate in vivo environment.
Seila, Selimović +2 more
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Advances in Organ-on-a-Chip Materials and Devices
ACS Applied Bio Materials, 2022The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical to clinical translational precision. The current trends in the in vitro modeling is to reduce the complexity of human organ anatomy to the fundamental cellular microanatomy as an alternative of recreating the entire cell milieu that allows systematic analysis of ...
Bishal Kumar Nahak +3 more
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Comprehensive Development in Organ-On-A-Chip Technology
Journal of Pharmaceutical Sciences, 2022The expeditious advancement in the organ on chip technology provided a phase change to the conventional in vitro tests used to evaluate absorption, distribution, metabolism, excretion (ADME) studies and toxicity assessments. The demand for an accurate predictive model for assessing toxicity and reducing the potential risk factors became the prime area ...
X, Joseph +3 more
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Emerging Biosensor Trends in Organ-on-a-Chip
2020Organ-on-a-chip technology is ideally suited to cultivate and analyze 2D/3D cell cultures, organoids, and other tissue analogues in vitro, because these microphysiological systems have been shown to generate architectures, structural organization, and functions that closely resemble their respective human tissues and organs. Although great efforts have
Mario, Rothbauer, Peter, Ertl
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Sensors and Biosensors in Organs-on-a-Chip Platforms
2022Biosensors represent a powerful analytical tool for analyzing biomolecular interactions with the potential to achieve real-time quantitative analysis with high accuracy using low sample volumes, minimum sample pretreatment with high potential for the development of in situ and highly integrated monitoring platforms.
Gerardo A, Lopez-Muñoz +2 more
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