Results 121 to 130 of about 5,802,173 (351)

An organ culture system to model early degenerative changes of the intervertebral disc

Arthritis Research & Therapy, 2011
IntroductionBack pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at symptomatic relief.
R. Ponnappan, D. Markova, Paul Jd Antonio, Hallie B Murray, Alexander R. Vaccaro, Irving M. Shapiro, G. Anderson, Todd J. Albert, M. Risbud   +8 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

How managers can build trust in strategic alliances: a meta-analysis on the central trust-building mechanisms [PDF]

, 2016
Trust is an important driver of superior alliance performance. Alliance managers are influential in this regard because trust requires active involvement, commitment and the dedicated support of the key actors involved in the strategic alliance.
A Ariño, A Joshi, A Parkhe, A Parkhe, A Parkhe, A Rindfleisch, A Rus, A Wong, A Zaheer, A Zaheer, A Zaheer, AC Inkpen, AC Inkpen, AI Huffcutt, B Anand, Carolin Decker, D Eden, D Rousseau, DA Harrison, DA Levinthal, DF Jennings, DJ McAllister, DM Rousseau, E Anderson, E Anderson, EM Whitener, FT Rothaermel, G Duysters, G Hofstede, I Geyskens, I Geyskens, J Bleeke, J Cohen, JB Heide, JE Hunter, JE Hunter, JH Dyer, JM Cortina, JM Geringer, KJ Mayer, L Poppo, L Poppo, L Rosenkopf, LG Zucker, M Bensaou, M Borenstein, M Fichman, M Zollo, Martina Lütkewitte, Matthias Meier, MJ Robson, MJ Robson, MW Lipsey, OE Williamson, OE Williamson, P Kale, P Kale, PS Ring, R Bachmann, R Bhattacharya, R Gulati, R Gulati, R Lunnan, R Rosenthal, R Seppänen, RC Mayer, RD Ireland, RM Kramer, RM Kramer, S Duval, S Ganesan, S Zaheer, SH Park, SP Deshpande, SS Lui, T Khanna, T Mellewigt, Thomas Mellewigt, TK Das, TK Das, Z Cao   +80 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Thidiazuron-induced shoot organogenesis from mature leaf explants of scented Pelargonium capitatum cultivars [PDF]

, 2011
Shoot organogenesis from mature leaf tissues of two scented Pelargonium capitatum cultivars, ‘Attar of Roses’ and ‘Atomic Snowflake’, grown in the greenhouse, were optimized in the presence of thidiazuron (TDZ).
Arshad, Muhammad, Dumat, Camille, Kallerhoff, Jean, Merlina, Georges, Pinelli, Eric, Silvestre, Jérôme   +5 more
core   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Human Organ Culture: Updating the Approach to Bridge the Gap from In Vitro to In Vivo in Inflammation, Cancer, and Stem Cell Biology

Frontiers in Medicine, 2017
Human studies, critical for developing new diagnostics and therapeutics, are limited by ethical and logistical issues, and preclinical animal studies are often poor predictors of human responses.
Rafia S. Al-Lamki, John R. Bradley, Jordan S. Pober   +2 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source