Results 1 to 10 of about 124,286 (260)

The nerve center of organ engineering [PDF]

Nature Communications
Engineering replacement organs is the next frontier in therapeutic technologies. Yet, the integration of innervation—critical for organ development, function, and homeostasis—remains underexplored.
Suradip Das, Wisberty J. Gordián-Vélez, Jay R. Dave, Zarina S. Ali, Harry C. Ledebur, D. Kacy Cullen   +5 more
doaj   +2 more sources

Ex vivo development of the entire mouse fetal reproductive tract by using microdissection and membrane-based organ culture techniques. [PDF]

Differentiation, 2022
Jia S, Zhao F.
europepmc   +2 more sources

Advances and Applications of Organ-on-a-Chip and Tissue-on-a-Chip Technology [PDF]

Bioengineering
Organ-on-a-chip (OoC) or tissue-on-a-chip (ToC) technologies represent a significant advancement in enabling modeling of human organ and tissue physiology for medical study, although further development is required for these technologies to reach ...
Megan Moore, Sashwat Sriram, Jennifer Ku, Yong Li   +3 more
doaj   +2 more sources

Design and Fabrication of Organ-on-Chips: Promises and Challenges

Micromachines, 2021
The advent of the miniaturization approach has influenced the research trends in almost all disciplines. Bioengineering is one of the fields benefiting from the new possibilities of microfabrication techniques, especially in cell and tissue culture ...
Alireza Tajeddin, Nur Mustafaoglu
doaj   +1 more source

Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function

Micromachines, 2021
Biological barriers are essential for the maintenance of organ homeostasis and their dysfunction is responsible for many prevalent diseases. Advanced in vitro models of biological barriers have been developed through the combination of 3D cell culture ...
Patrícia Zoio, Sara Lopes-Ventura, Abel Oliva   +2 more
doaj   +1 more source

Prospects for fertility preservation: the ovarian organ function reconstruction techniques for oogenesis, growth and maturation in vitro

Frontiers in Physiology, 2023
Today, fertility preservation is receiving more attention than ever. Cryopreservation, which preserves ovarian tissue to preserve fertility in young women and reduce the risk of infertility, is currently the most widely practiced.
Bai Hu, Bai Hu, Renjie Wang, Renjie Wang, Di Wu, Di Wu, Rui Long, Rui Long, Jinghan Ruan, Jinghan Ruan, Lei Jin, Ding Ma, Ding Ma, Chaoyang Sun, Chaoyang Sun, Shujie Liao, Shujie Liao   +16 more
doaj   +1 more source

An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

eLife, 2022
In recent years, live-imaging techniques have been developed for the adult midgut of Drosophila melanogaster that allow temporal characterization of key processes involved in stem cell and tissue homeostasis.
Marco Marchetti, Chenge Zhang, Bruce A Edgar   +2 more
doaj   +1 more source

Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy

Cancer Communications, 2021
Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell type, spatial organization, and microenvironment but also have adverse ...
Jingjing Qu, Farhin Shaheed Kalyani, Li Liu, Tianli Cheng, Lijun Chen   +4 more
doaj   +1 more source

Experimental liver models: From cell culture techniques to microfluidic organs‐on‐chip [PDF]

Liver International, 2021
AbstractThe liver is one of the most studied organs of the human body owing to its central role in xenobiotic and drug metabolism. In recent decades, extensive research has aimed at developing in vitro liver models able to mimic liver functions to study pathophysiological clues in high‐throughput and reproducible environments.
Polidoro M. A., Ferrari E., Marzorati S., Lleo A., Rasponi M.   +4 more
openaire   +2 more sources

Editorial for the Special Issue on Organs-on-Chips

Micromachines, 2020
Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices to model functional units of organs [...]
Yu-suke Torisawa, Yi-Chung Tung
doaj   +1 more source